{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:57:29Z","timestamp":1782737849259,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cryosurgery is a method of achieving lesion destruction by rapid freezing <jats:italic>in situ<\/jats:italic>. Application of cryosurgery in medicine widespread and its use within dentistry is also well documented, using both open and closed liquid nitrogen and carbon dioxide. The major advantages of oral cryosurgery include bloodless treatment, very low incidence of secondary infection, and a relative lack of scarring and pain. This review outlines knowledge on the mechanisms, tissue response, and current practices of cryosurgery in the oral and peri\u2010oral region. More experimental studies are needed to better understand this important modality at cellular and molecular levels. Inconsistency in the current protocols used for the treatment of the oral lesions is evident. Additional studies are needed to define the treatment protocols for different types of oral lesions. Information on the cryogen type and dose and the delivery technique required would help to produce reproducible outcomes for the treatment of targeted lesions.<\/jats:p>","DOI":"10.1111\/j.2041-1626.2012.00165.x","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T03:17:15Z","timestamp":1348456635000},"page":"71-77","source":"Crossref","is-referenced-by-count":17,"title":["Cryosurgery of the oral and peri\u2010oral region: a literature review of the mechanism, tissue response, and clinical applications"],"prefix":"10.1111","volume":"4","author":[{"given":"Omar","family":"Kujan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Faculty of Dentistry  Al\u2010Farabi College, Riyadh Kingdom of Saudi Arabia Kingdom of Saudi Arabia"},{"name":"Department of Oral Pathology and Medicine School of Dentistry, Al\u2010Baath University Hama Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh N.","family":"Azzeghaiby","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Faculty of Dentistry  Al\u2010Farabi College, Riyadh Kingdom of Saudi Arabia Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel","family":"Tarakji","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Faculty of Dentistry  Al\u2010Farabi College, Riyadh Kingdom of Saudi Arabia Kingdom of Saudi Arabia"},{"name":"Department of Oral Pathology and Medicine School of Dentistry Aleppo University, Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulwahab","family":"Abuderman","sequence":"additional","affiliation":[{"name":"School of Medicine King Fahd Medical City, Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah","family":"Sakka","sequence":"additional","affiliation":[{"name":"Department of Oral and 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