{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:26:59Z","timestamp":1780072019254,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Several epidemiologic studies have identified a greater incidence of periodontitis in patients with type 2 diabetes. Recent developments suggest that local delivery of antimicrobials into periodontal pockets improve periodontal health. The present study was designed to investigate the adjunctive effects of subgingivally delivered clarithromycin (<jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content>) (0.5% concentration) as an adjunct to scaling and root planing for treating chronic periodontitis in patients with well\u2010controlled type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010three patients were categorized into two treatment groups: <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 1, scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) plus 0.5% <jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content>; Group 2, <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> plus placebo gel. Clinical parameters were recorded at baseline, 1, 2, and 3\u00a0months; which included gingival index (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>), sulcus bleeding index (<jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content>), plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), and periodontal attachment level (<jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both therapies resulted in significant improvements. Using a subject\u2010based analysis, patients in Group 1 treated with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> showed enhanced reductions in <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SBI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, and gains in <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) over a period of 6\u00a0months as compared to <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although both treatment strategies seemed to benefit the patients, the adjunctive use of 0.5% <jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> as a controlled drug delivery system enhanced the clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.2041-1626.2012.00168.x","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T02:09:38Z","timestamp":1347674978000},"page":"276-283","source":"Crossref","is-referenced-by-count":17,"title":["Locally delivered 0.5% clarithromycin, as an adjunct to nonsurgical treatment in chronic periodontitis with well\u2010controlled type 2 diabetes: a randomized controlled clinical trial"],"prefix":"10.1111","volume":"3","author":[{"given":"Pavan","family":"Bajaj","sequence":"first","affiliation":[{"name":"Department of Periodontics Government Dental College and Research Institute Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A R","family":"Pradeep","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College and Research Institute 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