{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:43:09Z","timestamp":1771530189715,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"s39","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2011,8]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study:<\/jats:bold>\n D(+)\u2010xylose absorption tests are commonly performed when investigating suspected small intestinal malabsorption in the horse. The test involves the administration of a D(+)\u2010xylose solution via a nasogastric tube followed by serial blood sampling to determine its rate of absorption. In some horses, nasogastric intubation cannot be safely performed without prior administration of a sedative. Due to its short duration of action, the \u03b1\n 2<\/jats:sub>\n agonist xylazine is commonly used for this purpose. However, \u03b1\n 2<\/jats:sub>\n agonists have also been reported to influence the rate of gastric emptying as well as small intestinal motility patterns.\n <\/jats:p>\n \n Objective:<\/jats:bold>\n To evaluate if prior sedation with xylazine would influence the rate of absorption of D(+)\u2010xylose in 6 normal Standardbred horses in a randomised cross\u2010over study.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n D(+)\u2010xylose was administered by nasogastric intubation at a dose rate of 0.5\u2003g\/kg\u2003bwt given as a 10% solution with water while xylazine was administered iv at a dose rate of 0.5\u2003mg\/kg\u2003bwt. A heparinised blood sample was collected prior to administration of D(+)\u2010xylose (and xylazine when used) and then at 30, 45, 60, 75, 90, 120, 150, 180 and 240 min following administration. Samples were immediately analysed using a modified colorimetric micro method. The cumulative amount of D(+)\u2010xylose absorbed at each time point with and without prior sedation were. The significance rate was set at P<0.05.\n <\/jats:p>\n \n Results:<\/jats:bold>\n The study failed to demonstrate a statistically significant difference in the amount of D(+)\u2010xylose absorbed between sedated and unsedated animals, although there was a tendency for a less rapid initial uptake with prior sedation.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n This study suggests that prior sedation with xylazine will not significantly affect the result of a D(+)\u2010xylose absorption test in the normal horse.\n <\/jats:p>","DOI":"10.1111\/j.2042-3306.2011.00374.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T09:46:31Z","timestamp":1311673591000},"page":"149-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of sedation on D(+)\u2010xylose absorption tests in 6 normal horses"],"prefix":"10.1111","volume":"43","author":[{"given":"C.","family":"FINTL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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