{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:57:58Z","timestamp":1789721878218,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,6]],"date-time":"2012-05-06T00:00:00Z","timestamp":1336262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Reasons for performing study:<\/jats:bold>\n                    The sensitivity and specificity of basal plasma \u03b1\u2010melanocyte\u2010stimulating hormone (\u03b1\u2010MSH) and adrenocorticotrophic hormone (ACTH) for the diagnosis of pituitary pars intermedia dysfunction (PPID) has not been evaluated in a population\u2010based study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    To evaluate basal plasma \u03b1\u2010MSH and ACTH concentrations for the diagnosis of PPID in a population of horses aged \u226515 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Owner\u2010reported data were obtained using a postal questionnaire distributed to an equestrian group. A subgroup of surveyed owners was visited and veterinary examination performed on horses aged \u226515 years. Blood samples were analysed for plasma \u03b1\u2010MSH and ACTH concentrations. Seasonally adjusted cut\u2010off values for \u03b1\u2010MSH and ACTH concentrations for the diagnosis of PPID were obtained using Youden index values against a clinical gold standard diagnosis (hirsutism plus 3 or more clinical signs of PPID).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    \u03b1\u2010melanocyte\u2010stimulating hormone and ACTH were highly correlated with each other and with clinical and historical indicators of PPID. The increase in both \u03b1\u2010MSH and ACTH with increasing numbers of clinical signs in affected horses supports a spectrum of disease. Both variables were affected by season, with derived cut\u2010off values being higher in autumn compared with other seasons. Sensitivity and specificity were moderate and good in nonautumn seasons (59 and 93%, respectively) for \u03b1\u2010MSH using a cut\u2010off of 52.0\u2003pmol\/l. Sensitivity and specificity were good in nonautumn seasons (80 and 83%, respectively) for ACTH using a cut\u2010off of 29.7\u2003pg\/ml. For both \u03b1\u2010MSH and ACTH, sensitivity and specificity were close to 100% for samples obtained during the autumn period.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and potential relevance:<\/jats:bold>\n                    Basal plasma \u03b1\u2010MSH and ACTH had moderate\u2010to\u2010good sensitivity and specificity for the diagnosis of PPID, which improved substantially during the autumn period, suggesting this may be the ideal time to test. Further studies to develop seasonally adjusted reference intervals for different geographical locations are warranted.\n                  <\/jats:p>","DOI":"10.1111\/j.2042-3306.2012.00575.x","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T00:50:57Z","timestamp":1336351857000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Evaluation of basal plasma \u03b1\u2010melanocyte\u2010stimulating hormone and adrenocorticotrophic hormone concentrations for the diagnosis of pituitary pars intermedia dysfunction from a population of aged horses"],"prefix":"10.1111","volume":"45","author":[{"given":"T. W.","family":"MC GOWAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P.","family":"PINCHBECK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"MC GOWAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.02.001"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(02)00018-4"},{"key":"e_1_2_8_4_2","unstructured":"Schott H.C.Fun facts about pituitary pars intermedia dysfunction in horses.Proceedings in:Equine endocrinology summit Charleston SC USA.2011."},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2460\/javma.1994.204.04.627","article-title":"Diagnostic testing for pituitary pars\u2010intermedia dysfunction in horses","volume":"204","author":"Dybdal N.O.","year":"1994","journal-title":"J. Am. Vet. Med. 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