{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:32:10Z","timestamp":1780468330041,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"S43","license":[{"start":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T00:00:00Z","timestamp":1353974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reasons for performing study<\/jats:title>\n                    <jats:p>\n                      Early, accurate diagnosis of ascending placentitis in mares remains a key challenge for successful treatment of the disease.\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      oppler ultrasonography has shown promise as a tool to diagnose pregnancy abnormalities and is becoming more available to equine clinicians. However, to date, no studies have prospectively compared this technique to standard\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      \u2010mode measurement of the combined thickness of the uterus and placenta (\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The objective of the current study was to compare\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      oppler and\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      \u2010mode ultrasonography for the detection of experimentally\u2010induced ascending placentitis in mares.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eleven healthy pony mares in late gestation were used in this study. Placentitis was induced in 6 mares between\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      ays 280 and 295, while 5 mares served as negative controls. All mares were intensively monitored until delivery. Fetal heart rate,\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      , uterine artery blood flow (resistance index, pulsatility index, arterial diameter and total arterial blood flow) and physical examination findings were recorded at each examination. Mares with an increased\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      above published values were treated in accordance with published recommendations. Foals and fetal membranes were examined at birth. Ultrasonographic parameters were compared between groups using\n                      <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>\n                      . Foal viability and histological presence of placentitis were compared using a\n                      <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                      isher's exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      was increased above normal in 5 of 6 inoculated mares within 3 days after inoculation (\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      = 0.05). The sixth inoculated mare was excluded from subsequent data analysis. Uterine artery blood flow, physical examination findings and fetal heart rate were not different between groups. Gradual increases in\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      , arterial diameter and total arterial blood flow were detected with increasing gestational age in the control mares (\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      = 0.02,\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      = 0.00001 and\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      = 0.00001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      , but not uterine blood flow, was different between groups (\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      = 0.00001). Recorded\n                      <jats:styled-content style=\"fixed-case\">CTUP<\/jats:styled-content>\n                      values for control pony mares were similar to previously published values for light breed horses.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.2042-3306.2012.00658.x","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T18:33:25Z","timestamp":1354041205000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["B\u2010mode and\n                    <scp>D<\/scp>\n                    oppler ultrasonography in pony mares with experimentally induced ascending placentitis"],"prefix":"10.1111","volume":"44","author":[{"given":"C. S.","family":"Bailey","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Heitzman","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. N.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Bare","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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