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The response is dose-related, maximal water intake (6.1 \u00b1 0.55 mL; mean \u00b1 s.e.) occurring at 10 \u03bcg of bethanechol. Peripheral administration of the agonist (up to 3 mg kg\u22121 i.p.) fails to elicit drinking. Among several specific antagonists only anti-muscarinic drugs produced a significant inhibition of the response, suggesting that the compulsive drinking behaviour in the rat is caused by activation of central muscarinic receptors. The drinking behaviour emerges as a reliable test to assess central muscarinic activity of both agonists and antagonists.<\/jats:p>","DOI":"10.1111\/j.2042-7158.1987.tb06272.x","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T11:40:21Z","timestamp":1302694821000},"page":"304-306","source":"Crossref","is-referenced-by-count":8,"title":["Central muscarinic activation elicits compulsive drinking behaviour in the rat"],"prefix":"10.1093","volume":"39","author":[{"given":"A","family":"Schiavone","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Istituto De Angeli , via Serio 15, 20139 Milano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Prudentino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Istituto De Angeli , via Serio 15, 20139 Milano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Giachetti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Istituto De Angeli , via Serio 15, 20139 Milano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"2024110807223100300_cit1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.1970.sp009220","volume":"210","author":"Epstein","year":"1970","journal-title":"J. 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