{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:41:05Z","timestamp":1778820065381,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aristotelia chilensis leaves (Elaeocarpaceae) are used in Chilean folk medicine to treat pain and inflammation. A bioguided study was carried out on serial extracts (hexane, dichloromethane, methanol, aqueous extract (INFU) and a crude mixture of alkaloids (ALK-MIX). All extracts were evaluated for (1) topical administration against both arachidonic acid and 12-deoxyphorbol-13-decanoate (TPA)-induced inflammation in mice and (2) per-os administration against inflammation by \u03bb-carrageenan-induced paw oedema in guinea-pigs and (3) topical analgesia in tail flick and formalin models and per-os writhing test in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Greater anti-inflammatory effects were obtained against TPA with dichloromethane extract and methanol extract (63.9 and 66.0%, respectively). INFU showed the most potent effect (56.2%) against arachidonic acid. Greater effects were obtained in the writhing test with hexane and dichloromethane extracts (89.2% both). In the topical analgesia models, all the extracts and ALK-MIX were active with exception of the hexane extract in the formalin assay. In tail flick test, ALK-MIX and the methanol extract were the most active (58.2 and 55.2%, respectively). In relation to the tail formalin assay, the methanol extract (74.1%) was the most active. Concerning antioxidant activity, both INFU and the methanol extract were the most active either in the inhibition of xanthine oxidase (52.9 and 62.7%, respectively) or in the DPPH free radical scavenging activity (EC50 (concentration that produced 50% of activity) = 12.1 and 9.7 \u00b5g\/ml, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key findings<\/jats:title><jats:p>Aristoteline, aristone, serratoline and hobartinol were isolated from ALK-MIX. Ursolic acid, friedelin and quercetin 5,3\u2032-dimethyl ether were present in the dichloromethane extract while quercetin 3-O-\u03b2-d-glucoside and kaempferol were present in the methanol extract. From INFU were isolated protopine, aristoteline and caffeic and ferulic acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effects of A. chilensis are herein demonstrated, validating its use in traditional medicine. Protopine is reported for the first time in Elaeocarpaceae.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.2042-7158.2011.01280.x","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T08:49:51Z","timestamp":1304412591000},"page":"849-859","source":"Crossref","is-referenced-by-count":58,"title":["Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae"],"prefix":"10.1093","volume":"63","author":[{"given":"Orlando","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Christen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , Geneva,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvian","family":"Cretton","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , Geneva,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Backhouse","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Torres","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olosmira","family":"Correa","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edda","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Miranda","sequence":"additional","affiliation":[{"name":"Programa de Farmacolog\u00eda, ICBM, Facultad de Medicina, Universidad de Chile , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Delporte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas , Casilla, Santiago,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"2024103013291300200_cit1","first-page":"184","volume-title":"Medicina Tradicional Chilena","author":"Montes","year":"1977"},{"key":"2024103013291300200_cit2","first-page":"153","article-title":"Estudio qu\u00edmico de las especies de la familia Eleocapaceae que crecen en Chile","volume-title":"Qu\u00edmica de la Flora de Chile","author":"Silva","year":"1992"},{"key":"2024103013291300200_cit3","first-page":"225","article-title":"Screening of chilean plants for anticancer activity","volume":"39","author":"Bhakuni","year":"1976","journal-title":"J Nat Prod (Lloydia)"},{"key":"2024103013291300200_cit4","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.foodchem.2007.08.092","article-title":"Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae), maqui","volume":"107","author":"C\u00e9spedes","year":"2008","journal-title":"Food Chem"},{"key":"2024103013291300200_cit5","first-page":"45","article-title":"Plantas medicinales de uso en Chile. 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