{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:00:49Z","timestamp":1777658449233,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Restoration of epithelial continuity in the intestinal surface after extensive destruction is important since intestinal epithelial cells stand as a boundary between the body's internal and external environment. Polysaccharides from Ganoderma lucidum (Gl-PS) may benefit intestinal epithelial wound healing in different aspects, which awaits clarification. To identify potential effects, a non-transformed small-intestinal epithelial cell line, IEC-6 cells, was used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Effects on epithelial cell proliferation, migration, morphology of differentiation and transforming growth factor beta (TGF-\u03b2) protein expression, as well as the cellular ornithine decarboxylase (ODC) mRNA and c-Myc mRNA expression, were assessed, respectively, by MTT assay, wound model in vitro, observation under a microscope after hematoxylin and eosin staining, enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>It was shown that Gl-PS stimulated IEC-6 cell proliferation and migration significantly in a dose-dependent manner; 10 \u00b5g\/ml Gl-PS improved the morphology of differentiation in IEC-6 cells. Inefficacy in expression of TGF-\u03b2 in IEC-6 cells indicated a possible TGF-\u03b2 independent action of Gl-PS. However, Gl-PS increased ODC mRNA and c-Myc mRNA expression in a dose-dependent manner, indicating, at least partially possible involvement of ODC and c-Myc gene expression in improvement of intestinal wound healing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results suggest the potential usefulness of Gl-PS to cure intestinal disorders characterized by injury and ineffective repair of the intestinal mucosa.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/j.2042-7158.2011.01367.x","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T02:20:42Z","timestamp":1318558842000},"page":"1595-1603","source":"Crossref","is-referenced-by-count":20,"title":["Effects of <i>Ganoderma lucidum<\/i> polysaccharides on IEC-6 cell proliferation, migration and morphology of differentiation benefiting intestinal epithelium healing <i>in vitro<\/i>"],"prefix":"10.1093","volume":"63","author":[{"given":"Li-Xin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]},{"name":"Affiliated Hospital of Chengde Medical College , Chengde, Hebei Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]},{"name":"Changsha Medical University , Changsha, Hunan Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Ye","sequence":"additional","affiliation":[{"name":"Tianjing Medical University , Tianjing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Basic Medical School, Peking University Health Science Center , Beijing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"2024103013285311500_cit1","first-page":"G495","article-title":"Mucosal immunity and inflammation. 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