{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T04:32:53Z","timestamp":1730349173845,"version":"3.28.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to determine the anti-arthritis effect and its mechanism of a combination of herbal extracts from Trachelospermi caulis (TC) and Moutan cortex radicis (MC) (TCMC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The anti-arthritis activity of TCMC was assessed using a mouse model of type II collagen-induced arthritis (CIA). Reverse transcriptase-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), electrophoretic mobility shift assay (EMSA) and other biological assays were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>TCMC significantly ameliorated various inflammatory parameters, such as clinical arthritis index, histological deformation of joints, serum levels of rheumatoid arthritis biomarkers (cartilage oligomeric matrix protein, serum amyloid P and anti-collagen type II IgG antibody), and Th1-related responses (T cell proliferation, and production of Interferon-\u03b3 and interleukin (IL)-2 in splenocytes isolated from CIA mice). The production of matrix metalloproteinases (MMPs), pro-inflammatory cytokines (tumour necrosis factor-\u03b1, IL-1\u03b2 and IL-6) and chemokines (macrophage inflammatory protein-1, monocyte chemoattractant protein-1, and Regulated upon Activation, Normal T-cell Expressed, and Secreted) was suppressed by TCMC in CIA mice. In addition, the number of osteoclasts in the hind tibia was significantly decreased. With regard to the mechanism, TCMC suppressed the activation of the transcription factors nuclear factor (NF)-\u03baB and activator protein (AP)-1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>TCMC exerts an anti-arthritis effect in CIA mice by suppression of the production of various inflammatory factors and the formation of osteoclasts through the inhibition of NF-\u03baB and AP-1 activation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/j.2042-7158.2011.01415.x","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T04:26:30Z","timestamp":1323404790000},"page":"420-429","source":"Crossref","is-referenced-by-count":11,"title":["A mixture of Trachelospermi caulis and Moutan cortex radicis extracts suppresses collagen-induced arthritis in mice by inhibiting NF-<i>\u03ba<\/i>B and AP-1"],"prefix":"10.1093","volume":"64","author":[{"given":"Hyuk Soon","family":"Kim","sequence":"first","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Ram","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, Sinil Pharmaceutical Co., Ltd , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, Sinil Pharmaceutical Co., Ltd , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, Sinil Pharmaceutical Co., Ltd , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bokyung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erk","family":"Her","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mok","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University , Busan,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Duksung Women's University , Seoul,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahn Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Medicine and Institute of Biomedical Science and Technology, Konkuk University , Chungju,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"2024103013321125700_cit1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/ar2535","article-title":"Developments in the clinical understanding of rheumatoid arthritis","volume":"11","author":"Smolen","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"2024103013321125700_cit2","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1002\/1529-0131(200110)44:10<2263::AID-ART389>3.0.CO;2-1","article-title":"Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 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