{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:31:59Z","timestamp":1785547919798,"version":"3.56.0"},"reference-count":114,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Epigenetics refers to the heritable, but reversible regulation of various biological functions. Changes in DNA methylation and chromatin structure derived from histone modifications are involved in the brain development, pathogenesis and pharmacotherapy of brain disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Evidence suggests that epigenetic modulations play key roles in psychiatric diseases such as schizophrenia and bipolar disorder. The analysis of epigenetic aberrations in the mechanisms of psychoactive drugs helps to determine dysfunctional genes and pathways in the brain, to predict side effects of drugs on human genome and identify new pharmaceutical targets for treatment of psychiatric diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Although numerous studies have concentrated on epigenetics of psychosis, the epigenetic studies of antipsychotics are limited. Here we present epigenetic mechanisms of various psychoactive drugs and review the current literature on psychiatric epigenomics. Furthermore, we discuss various epigenetic modulations in the pharmacology and toxicology of typical and atypical antipsychotics, methionine, lithium and valproic acid.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/j.2042-7158.2012.01475.x","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T04:14:08Z","timestamp":1333944848000},"page":"1349-1358","source":"Crossref","is-referenced-by-count":23,"title":["Epigenetics of psychoactive drugs"],"prefix":"10.1093","volume":"64","author":[{"given":"Nadka","family":"Boyadjieva","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical Faculty, Medical University , Sofia,","place":["Bulgaria"]},{"name":"Department of Animal Sciences, Cook College, Rutgers University , New Brunswick, NJ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Varadinova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical Faculty, Medical University , Sofia,","place":["Bulgaria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2024103013313081200_cit1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.schres.2007.09.020","article-title":"Histone deacetylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection","volume":"98","author":"Sharma","year":"2008","journal-title":"Schizophr Res"},{"key":"2024103013313081200_cit2","first-page":"351","article-title":"Histone acetylation and methylation: combinatorial players for transcriptional regulation","volume":"41","author":"An","year":"2007","journal-title":"Subcell Biochem"},{"key":"2024103013313081200_cit3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0955-0674(00)00208-8","article-title":"Histone methylation 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