{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:34:48Z","timestamp":1760488488154,"version":"3.28.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this work was to study the effects of P. major against the oxidative damage of isolated rat liver mitochondria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The extracts were obtained using methanol (MeOH), ethyl acetate (EAc), dichloromethane (DCM), and hexane (Hex) as solvents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Hex, DCM, and EAc totally, and MeOH partially, inhibited ROS generation and lipid peroxidation of membranes induced by Fe2+ or t-BOOH. However, only MeOH was able to prevent the t-BOOH-induced glutathione and NAD(P)H oxidation. All extracts chelated Fe2+ and reduced DPP Hradicals. EPR analysis revealed that P. major exhibited potent scavenger activity for hydroxyl radicals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The potent antioxidant activity exhibited by P. major was able to prevent oxidative mitochondrial damage, contributing to the understanding of its hepatoprotective action against ROS-mediated toxicity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/j.2042-7158.2012.01496.x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T07:27:08Z","timestamp":1332487628000},"page":"1177-1187","source":"Crossref","is-referenced-by-count":13,"title":["Hydroxyl scavenging activity accounts for differential antioxidant protection of <i>Plantago major<\/i> against oxidative toxicity in isolated rat liver mitochondria"],"prefix":"10.1093","volume":"64","author":[{"given":"Joyce C","family":"Mello","sequence":"first","affiliation":[{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Bioqu\u00edmica, Universidade de Mogi das Cruzes (UMC) , Mogi das Cruzes, SP,","place":["Brazil"]},{"name":"Centro de Ci\u00eancias Naturais e Humanas, Universidade Federal do ABC , Santo Andr\u00e9, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia S S","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Bioqu\u00edmica, Universidade de Mogi das Cruzes (UMC) , Mogi das Cruzes, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano V D","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Bioqu\u00edmica, Universidade de Mogi das Cruzes (UMC) , Mogi das Cruzes, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana S","family":"Paiva","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Bioqu\u00edmica, Universidade de Mogi das Cruzes (UMC) , Mogi das Cruzes, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Prieto","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo , S\u00e3o Carlos, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otaciro R","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo , S\u00e3o Carlos, SP,","place":["Brazil"]},{"name":"Centro de Ci\u00eancias Naturais e Humanas, Universidade Federal do ABC , Santo Andr\u00e9, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Bioqu\u00edmica, Universidade de Mogi das Cruzes (UMC) , Mogi das Cruzes, SP,","place":["Brazil"]},{"name":"Centro de Ci\u00eancias Naturais e Humanas, Universidade Federal do ABC , Santo Andr\u00e9, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"2024103013323159600_cit1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0891-5849(00)00317-8","article-title":"Mitochondrial free radical generation, oxidative stress, and aging","volume":"29","author":"Cadenas","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"2024103013323159600_cit2","volume-title":"Free Radicals in Biology and 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