{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:42:04Z","timestamp":1759941724413,"version":"3.37.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005285","name":"FAPEG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We have investigated the anti-inflammatory and antinociceptive effects of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol (LQFM-015), which was designed through molecular simplification strategy from 4-nerolidylcatechol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The possible anti-inflammatory and antinociceptive effects were assayed on carrageenan-induced paw oedema and pleurisy, acetic acid-induced abdominal writhing and formalin tests in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>LQFM-015 reduced the activity of PLA2 enzyme in vitro by 18%. Docking studies into the catalytic site of PLA2 were used to identify the binding mode of the LQFM-015. LQFM-015 showed a moderate antinociceptive effect, since this compound reduced the number of writhings by approximately up to 40% in the acetic acid-induced pain model; this antinociceptive activity also emerged in the second phase of the formalin-induced pain model (58% of inhibition). The anti-inflammatory action of LQFM-015 was confirmed in acute inflammation models, in which it reduced the formation of oedema to 52.78 \u00b1 8.6 and 46.64 \u00b1 5.2 at the second and third hour of carrageenan-induced paw oedema, respectively. Also in the carrageenan-induced pleurisy model, LQFM-015 reduced the migration of leucocytes by 26.0% and decrease myeloperoxidase activity by 50%. LQFM-015 showed different concentrations to inhibit 50% of isoenzyme cyclooxygenase activity (IC50); COX-1 IC50 = 36 \u03bcm) and COX-2 IC50 = 28 \u03bcm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LQFM-015 demonstrated inhibition of both PLA2 and COX enzymes; thus, the moderate antinociceptive effect of this compound could be attributed to its anti-inflammatory activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/j.2042-7158.2012.01582.x","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T10:50:41Z","timestamp":1346237441000},"page":"133-141","source":"Crossref","is-referenced-by-count":11,"title":["Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol"],"prefix":"10.1093","volume":"65","author":[{"given":"Roberta Campos","family":"Lino","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Institute of Biological Sciences, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiula Ines","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Medicinal Pharmaceutical Chemistry, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iziara Ferreira","family":"Florentino","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Medicinal Pharmaceutical Chemistry, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Vinicius Mariano","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Medicinal Pharmaceutical Chemistry, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablinny Moreira","family":"Galdino","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Institute of Biological Sciences, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina H","family":"Andrade","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Molecular Modeling, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00eannia Rocha","family":"Rezende","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Biopharmacy and Pharmacokinetic, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Menegatti","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Medicinal Pharmaceutical Chemistry, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Institute of Biological Sciences, Federal University of Goi\u00e1s , Goi\u00e2nia,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2024103109170685900_jphp1582-cit-0001","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jep.2010.01.041","article-title":"The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. 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