{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:01:16Z","timestamp":1778623276034,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The medical treatment is indicated in the development stage of Peyronie's disease (\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ) for at least 1\u00a0year after diagnosis and whenever in case of penile pain. This research was conducted to demonstrate the possible effectiveness of vitamin E in\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    treatment, whereas in the scientific literature this topic is much discussed. A total of 70 patients (age:26\u201369\u00a0years, mean: 54.1\u00a0\u00b1\u00a09.71) diagnosed with\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    were enrolled in a conservative treatment. In addition to medical histories and physical examinations all patients underwent the following tests: International Index of Erectile Function (\n                    <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                    ) questionnaire, penile ultrasound and photographic documentation, pain evaluation by a conventional 10\u2010point pain scale Visual analogue pain scale (\n                    <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                    ). All 70 patients were divided into two different treatment groups: A and B, with different combinations of drugs: A\u00a0=\u00a0vitamin E\u00a0+\u00a0verapamil (injection\u00a0+\u00a0iontophoresis)\u00a0+\u00a0blueberries\u00a0+\u00a0propolis\u00a0+\u00a0topical diclofenac; B\u00a0=\u00a0verapamil (injection\u00a0+\u00a0iontophoresis)\u00a0+\u00a0blueberries\u00a0+\u00a0propolis\u00a0+\u00a0topical diclofenac. All patients were treated for 6\u00a0months after which they underwent the same follow\u2010up tests as performed prior to the treatment. Intergroup analysis revealed statistically significant differences: in the vitamin E group the effective plaque size reduction was \u221250.2% whereas in the control group the reduction was \u221235.8% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.027). In group A the improvement of curvature occurred in 96.6% of the cases whereas in the control group B this occurred in 48.4% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0001), moreover, the mean curvature decrease was respectively \u221212.25\u00b0 and \u22126.73\u00b0 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01).\n                    <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                    score was significantly improved in group A patients with comorbidities and erectile dysfunction (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.025). Increase in plaque size occurred only in the control group (17.1%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.032). We can affirm that vitamin E can help to prevent the progression of\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    . This study strongly supports the recommendation that the best approach for treating\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    is multimodal therapy.\n                  <\/jats:p>","DOI":"10.1111\/j.2047-2927.2012.00007.x","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T08:44:36Z","timestamp":1347007476000},"page":"120-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Efficacy of vitamin\n                    <scp>E<\/scp>\n                    in the conservative treatment of\n                    <scp>P<\/scp>\n                    eyronie's disease: legend or reality? A controlled study of 70 cases"],"prefix":"10.1111","volume":"1","author":[{"given":"G.","family":"Paulis","sequence":"first","affiliation":[{"name":"Andrology Service Regina Apostolorum Hospital  Albano Laziale Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Brancato","sequence":"additional","affiliation":[{"name":"Complex Operative Unit of Urology Regina Apostolorum Hospital  Albano Laziale Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Complex Operative Unit of Urology Regina Apostolorum Hospital  Albano Laziale Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"De Giorgio","sequence":"additional","affiliation":[{"name":"Andrology Jewish Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Nupieri","sequence":"additional","affiliation":[{"name":"Complex Operative Unit of Urology Regina Apostolorum Hospital  Albano Laziale Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Orsolini","sequence":"additional","affiliation":[{"name":"Complex Operative Unit of Urology Regina Apostolorum Hospital  Albano Laziale Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Alvaro","sequence":"additional","affiliation":[{"name":"Department of Public Health and Cellular Biology University of Rome \u2018Tor Vergata\u2019  Rome 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