{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:50:04Z","timestamp":1780087804487,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:00:00Z","timestamp":1349740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The ratio of second to fourth digit length (2D:4D) is a correlate of prenatal testosterone. High 2D:4D is associated with low prenatal testosterone, and reduced sensitivity to testosterone. Klinefelter's syndrome (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>; 47 <jats:styled-content style=\"fixed-case\">XXY<\/jats:styled-content>) affects the endocrine system, such that low testosterone levels are found in <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> foetuses, new\u2010borns and adults. To date, there are no published data regarding the pattern of 2D:4D in <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> males. Here we consider 2D:4D in <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a051), their relatives (16 fathers and 15 mothers) and an unaffected control sample of 153 men and 153 women. Adult <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> individuals were taller than their fathers and had shorter fingers than fathers and male controls. Compared with fathers, male controls and mothers, <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> males had shorter fingers relative to height. With regard to 2D:4D, <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> individuals had higher 2D:4D than fathers (right and left hands), male controls (right and left hands) and mothers (left hands). Among <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> males older than 13\u00a0years there were 34 individuals currently prescribed testosterone and nine not prescribed. In comparison to the former, the latter individuals had higher right 2D:4D and higher right\u2013left 2D:4D. We conclude that <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> males have mean 2D:4D values similar to those found in female population norms. In addition, testosterone supplementation in <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> males may be most common for individuals with low right 2D:4D.<\/jats:p>","DOI":"10.1111\/j.2047-2927.2012.00013.x","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T03:25:49Z","timestamp":1349839549000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Digit ratio (2D:4D) in Klinefelter's syndrome"],"prefix":"10.1111","volume":"1","author":[{"given":"J. T.","family":"Manning","sequence":"first","affiliation":[{"name":"Department of Psychology Swansea University Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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