{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:39:08Z","timestamp":1770701948281,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:00:00Z","timestamp":1349740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In humans, recent studies have correlated anogenital distance (<jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content>) in adult men to intrinsic testicular function. Although rodent studies suggest that <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content> is determined in utero and remains constant in adult life, it is not certain if <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content> remains constant across a man's adult life. We sought to determine if adult male <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content> varies based on age. A cross\u2010sectional study of men being evaluated at a men's health clinic. Anogenital distance (the distance from the posterior aspect of the scrotum to the anal verge) and penile length (<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>) were measured using digital callipers. <jats:sc>anova<\/jats:sc> and linear regression were used to determine correlations between <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content>, fatherhood status and age. In all, 473 men were included in the analysis with a mean age of 43\u00a0\u00b1\u00a013\u00a0years. The mean <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content> for the group was 39\u00a0\u00b1\u00a013\u00a0mm. Anogenital distance did not vary between age categories for the entire group, for fathers, and for childless men. Moreover, penile length also remained constant across age categories. On adjusted analyses stratified by fatherhood status, there was no relationship between <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content>p and age. The current cross\u2010sectional study demonstrates that anogenital distance, defined as the distance from the posterior scrotum to the anal verge, is similar for men of different ages. As such, <jats:styled-content style=\"fixed-case\">AGD<\/jats:styled-content> may provide a measure for genital development and function throughout adult life. However, confirmation with longitudinal studies is needed.<\/jats:p>","DOI":"10.1111\/j.2047-2927.2012.00019.x","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T06:17:57Z","timestamp":1349763477000},"page":"90-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The relationship between anogenital distance and age"],"prefix":"10.1111","volume":"1","author":[{"given":"M. L.","family":"Eisenberg","sequence":"first","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u2010C.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Male Reproductive Medicine and Surgery Scott Department of Urology Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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