{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:21:30Z","timestamp":1768818090278,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T00:00:00Z","timestamp":1350950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Men with a history of congenital undescended testes (<jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content>) have an increased risk of fertility problems. Despite no definitive proof, current guidelines recommend early surgical intervention because this may have a positive effect on future fertility potential by preventing degenerative changes of the testes in early life. Also surgical intervention facilitates observability of the testes in view of possible malignancy. We evaluated testicular function in adult men with previous <jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content> treated at different ages before puberty. A long\u2010term follow\u2010up study of men with previous <jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content> was performed. Andrological evaluation included medical history taking, physical examination, scrotal ultrasound, determination of reproductive hormones, and semen analysis. Findings were compared with those of a control group of men with normal testicular descent. The influence of age at orchiopexy on future fertility parameters was evaluated in a multivariate regression analysis. 62 men were included of whom seven had had bilateral <jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content>. Twenty\u2010four patients had had their orchiopexy before the age of 24\u00a0months of whom eight men had it before 12\u00a0months of age. Forty\u2010eight men had had unsuccessful luteinizing\u2010hormone\u2010releasing\u2010hormone (<jats:styled-content style=\"fixed-case\">LHRH<\/jats:styled-content>) nasal spray treatment during childhood, whereas 14 of 24 men operated before 24\u00a0months of age had not received <jats:styled-content style=\"fixed-case\">LHRH<\/jats:styled-content> treatment before orchiopexy. Fertility potential in men with a history of <jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content> is compromised in comparison with controls. We could not detect any influence of age at orchiopexy on fertility parameters. However, the number of patients operated before the age of 12\u00a0months is limited. This study does not support the assumption that early orchiopexy results in better fertility potential.<\/jats:p>","DOI":"10.1111\/j.2047-2927.2012.00024.x","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T08:06:57Z","timestamp":1350979617000},"page":"100-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Fertility potential in men with a history of congenital undescended testes: a long\u2010term follow\u2010up study"],"prefix":"10.1111","volume":"1","author":[{"given":"J.","family":"van Brakel","sequence":"first","affiliation":[{"name":"Department of Urology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kranse","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M. P. F.","family":"de Muinck Keizer\u2010Schrama","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Endocrinology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E. J.","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Endocrinology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. H.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Endocrinology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Bangma","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. W. J.","family":"Hazebroek","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. R.","family":"Dohle","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,23]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","year":"2010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.12.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241171"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.01.088"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1991.tb15325.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66392-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67763-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049959"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68040-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.05013.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00560-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00662.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000179304"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80732-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0435"},{"issue":"2","key":"e_1_2_8_17_1","first-page":"S11","article-title":"Histologic maldevelopment of unilaterally cryptorchid testes and their descended partners","volume":"152","author":"Huff DS","year":"1993","journal-title":"European Journal of Pediatrics"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049957"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.173"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.01.017"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049960"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65241-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb07375.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90986-4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00159.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9318-y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64505-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65946-9"},{"key":"e_1_2_8_29_1","volume-title":"Guidelines on Paediatric Urology","author":"Tekgul S","year":"2011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20723"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm027"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2005.11.007"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.2047-2927.2012.00024.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.2047-2927.2012.00024.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T01:10:07Z","timestamp":1698628207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.2047-2927.2012.00024.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,23]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.2047-2927.2012.00024.x"],"URL":"https:\/\/doi.org\/10.1111\/j.2047-2927.2012.00024.x","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,23]]},"assertion":[{"value":"2012-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}