{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:55:32Z","timestamp":1793746532191,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The sperm chromatin structure assay (SCSA) parameter DNA fragmentation Index (DFI) is a valuable tool for prediction of fertility in vivo. Clinical data show that a DFI above 30% is associated with very low chance for achieving pregnancy by natural conception or by insemination. Already when DFI is above 20% the chance of natural pregnancy is reduced, this despite normal conventional semen parameters. The aim of the present study was to investigate the prevalence of high DFI in male partners of unexplained infertile couples to further identification of male factors contributing to subfertility. Among 212 consecutive men under infertility investigation, 122 cases with the diagnosis \u2018unexplained infertility\u2019 were identified. For all but three, SCSA data were available. The percentage of couples with diagnosis \u2018unexplained infertility\u2019 in which the male partner has DFI &gt;20% or DFI &gt;30% was calculated. In the group diagnosed with \u2018unexplained infertility\u2019 17.7% of the men (95% CI 10.8\u201324.5) presented with 20 \u2264DFI &lt;30 and 8.4% (95% CI 3.40\u201313.4) had DFI \u226530%. A significant part of men diagnosed as unexplained infertile according to traditional diagnostic methods has remarkably high degrees of fragmented sperm DNA. Apart from adding to our understanding of biology of infertility our finding has clinical implications. Couples in which the DFI of the male partner is high can avoid prolonged attempts to become spontaneously pregnant or referral for intrauterine insemination, both having low chances of leading to conception.<\/jats:p>","DOI":"10.1111\/j.2047-2927.2012.00041.x","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T13:07:15Z","timestamp":1355490435000},"page":"357-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Prevalence of high DNA fragmentation index in male partners of unexplained infertile couples"],"prefix":"10.1111","volume":"1","author":[{"given":"K.","family":"Oleszczuk","sequence":"first","affiliation":[{"name":"Reproductive Medicine Centre Sk\u00e5ne University Hospital Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Augustinsson","sequence":"additional","affiliation":[{"name":"Reproductive Medicine 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