{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:26:09Z","timestamp":1775784369701,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T00:00:00Z","timestamp":1358035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast\u2010derived hormone osteocalcin (<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>) on testosterone production in mice, we investigated whether such an association can be replicated in humans. We used data from 1338 men (25\u201386\u00a0years) in the population\u2010based epidemiological Study of Health in Pomerania and from 110 male outpatients with bone disorders (18\u201385\u00a0years) for the study. We analysed cross\u2010sectional associations between <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> and total testosterone serum concentrations (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>), as well as associations between further markers of bone turnover [bone\u2010specific alkaline phosphatase (<jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>), serum C\u2010terminal telopeptides of Type I collagen (<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>), urinary deoxypyridinoline] and <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> using ordinary least square (<jats:styled-content style=\"fixed-case\">OLS<\/jats:styled-content>) regression models. Multivariable <jats:styled-content style=\"fixed-case\">OLS<\/jats:styled-content> models revealed a positive association between <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> in the population\u2010based (\u03b2 coefficients for a one standard deviation increase, 0.590; standard error (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>), 0.175; <jats:italic>p<\/jats:italic>\u2010value, &lt;0.01) and patient\u2010based (\u03b2 coefficient, 0.575; <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, 0.132; <jats:italic>p<\/jats:italic>\u2010value, &lt;0.01) samples even after adjustment for age and body mass index (both samples), and time of blood sampling (population\u2010based sample only). Furthermore, we observed positive associations between <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> (\u03b2 coefficient, 0.403; <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, 0.170; <jats:italic>p<\/jats:italic>\u2010value, 0.02) as well as between <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> (\u03b2 coefficient, 0.733; <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, 0.172; <jats:italic>p<\/jats:italic>\u2010value, &lt;0.01) in men from the general population. The present investigation shows that <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> is associated with <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> in the general population and in patients with bone disorders, and may thus indicate general male health status. Additional longitudinal observational studies are warranted to confirm our findings and future experimental research is necessary to elucidate potential mechanisms underlying the observed associations.<\/jats:p>","DOI":"10.1111\/j.2047-2927.2012.00044.x","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T03:42:45Z","timestamp":1358134965000},"page":"469-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders"],"prefix":"10.1111","volume":"1","author":[{"given":"A.","family":"Hannemann","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Breer","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wallaschofski","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nauck","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Baumeister","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Barvencik","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Schinke","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf Hamburg 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