{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:32:32Z","timestamp":1791181952840,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T00:00:00Z","timestamp":1328745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2012,4]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>We performed this study to examine the metabolic differences arising from higher liver fat accumulation in obese H<\/jats:styled-content>ispanic adolescents, with a particular focus on circulating levels of adipocytokines and insulin resistance.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010one obese H<\/jats:styled-content>ispanic adolescents (15.3\u2009\u00b1\u20091.0\u2009years, body mass index percentile: 97.0\u2009\u00b1\u20093.9) were assessed for: visceral adipose tissue (VAT<\/jats:styled-content>), subcutaneous adipose tissue (SAT<\/jats:styled-content>) and hepatic fat fraction (HFF<\/jats:styled-content>) by magnetic resonance imaging; fasting measures of serum glucose, insulin and adipocytokines; homeostasis model assessment of insulin resistance (HOMA\u2010IR<\/jats:styled-content>); and insulin sensitivity (SI<\/jats:styled-content>) and the acute insulin response to glucose (AIR<\/jats:styled-content>) by intravenous glucose tolerance test. Subjects with normal levels of HFF<\/jats:styled-content> (below 5%; n<\/jats:styled-content><\/jats:italic>\u2009=\u200925) were compared to those with HFF<\/jats:styled-content> >\u20095% (n<\/jats:styled-content><\/jats:italic>\u2009=\u200916).<\/jats:p><\/jats:sec>Results<\/jats:title>The two groups differing in HFF<\/jats:styled-content> were similar for total body fat, VAT<\/jats:styled-content> and SAT<\/jats:styled-content>. The group with HFF<\/jats:styled-content> >\u20095% had significantly (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05) higher interleukin\u20108 (IL<\/jats:styled-content>\u20108) (6.1\u2009\u00b1\u20091.6 vs. 3.2\u2009\u00b1\u20090.4\u2009pg\u2009mL\u22121<\/jats:sup>), NGF<\/jats:styled-content> (30.2\u2009\u00b1\u20099.9 vs. 13.9\u2009\u00b1\u20091.6\u2009pg\u2009mL\u22121<\/jats:sup>), HOMA\u2010IR<\/jats:styled-content> (8.8\u2009\u00b1\u20091.1 vs. 5.5\u2009\u00b1\u20090.5), AIR<\/jats:styled-content> (1869\u2009\u00b1\u2009206 vs. 1092\u2009\u00b1\u2009165) and a tendency for lower SI<\/jats:styled-content> (1.2\u2009\u00b1\u20090.4 vs. 2.1\u2009\u00b1\u20090.3; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.06), with no significant differences in any of other factors measured.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These data suggest that elevated liver fat is most closely associated with elevated serum IL<\/jats:styled-content>\u20108 and NGF<\/jats:styled-content> levels as well as increased AIR<\/jats:styled-content> and HOMA\u2010IR<\/jats:styled-content>. These elevated factors may play significant roles in the metabolic abnormalities associated with elevated liver fat in obese H<\/jats:styled-content>ispanics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.2047-6310.2011.00014.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T13:03:53Z","timestamp":1328792633000},"page":"158-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese H<\/scp>ispanic adolescents"],"prefix":"10.1111","volume":"7","author":[{"given":"J. S.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Childhood Obesity Research Center Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Department of Pediatrics Ulsan University Hospital University of Ulsan College of Medicine Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010A.","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Childhood Obesity Research Center Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mahurkar","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Childhood Obesity Research Center Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Childhood Obesity Research Center Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. I.","family":"Goran","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Childhood Obesity Research Center Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Department of Physiology and Biophysics Keck School of Medicine University of Southern California Los Angeles CA 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