{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:20:57Z","timestamp":1782962457184,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate changes in volatile organic compounds (<jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s) in exhaled breath in overweight\/obese children compared with their lean counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (<jats:styled-content style=\"fixed-case\">SIFT\u2010MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty overweight\/obese children and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.1\u2009\u00b1\u20092.8 vs. 12.1\u2009\u00b1\u20093.0 years), taller (164.8\u2009\u00b1\u200910.9 vs. 153.3\u2009\u00b1\u200917.1\u2009cm) and more likely to be Caucasian (60% vs. 35.2%); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for all. A comparison of the <jats:styled-content style=\"fixed-case\">SIFT\u2010MS<\/jats:styled-content> results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s can identify the presence of overweight\/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1\u2010decene, 1\u2010octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (<jats:italic>P<\/jats:italic> value\u2009&lt;\u20090.01 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obese children have a unique pattern of exhaled <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s. Changes in <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.2047-6310.2014.221.x","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T12:35:08Z","timestamp":1395923708000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls"],"prefix":"10.1111","volume":"10","author":[{"given":"N.","family":"Alkhouri","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Cleveland Clinic  Cleveland OH USA"},{"name":"Digestive Disease Institute Cleveland Clinic  Cleveland OH USA"},{"name":"Center for Cardiovascular Diagnostics and Prevention Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cikach","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Lerner Research Institute Cleveland Clinic  Cleveland OH USA"},{"name":"Department of Pulmonary, Allergy and Critical Care Medicine Respiratory Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Brindle","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rome","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hanouneh","sequence":"additional","affiliation":[{"name":"Digestive Disease Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Lerner Research Institute Cleveland Clinic  Cleveland OH USA"},{"name":"Department of Pulmonary, Allergy and Critical Care Medicine Respiratory Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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