{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:06:18Z","timestamp":1780607178697,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>PROBLEM: To compare changes in serum vascular endothelial growth factor (VEGF) levels during normal and <jats:italic>in vitro<\/jats:italic> fertilization \n(IVF) cycles.\nMETHOD OF STUDY: Ten healthy women with ovulatory cycles and 37 infertile \nwomen participating in an IVF program were followed by frequent serum \nsamples and with VEGF measurements throughout their cycles.\nRESULTS: Serum VEGF remained unchanged during the normal menstrual cycle, \nwhereas the IVF program participants showed elevations in serum VEGF in \nthe luteal phase of the cycle. When data from controls and patients were \npooled, redundant midluteal VEGF level correlated with progesterone and \nwith peak follicular phase estrogen level. The midluteal VEGF level in \nthe IVF cycles was associated with body mass index (<jats:italic>P<\/jats:italic>&lt;0.01) and \nprogesterone level (<jats:italic>P<\/jats:italic>&lt;0.05) by multiple regression. The 14 women conceiving tended to have higher VEGF levels than those failing to become pregnant. CONCLUSIONS: The IVF program was associated with increased synthesis of VEGF either in the ovaries, endometrium, or at other sites and this may be of significance for the outcome of IVF.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2000.430105.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:54:47Z","timestamp":1071662087000},"page":"25-30","source":"Crossref","is-referenced-by-count":13,"title":["No Cyclicity in Serum Vascular Endothelial Growth Factor During Normal Menstrual Cycle but Significant Luteal Phase Elevation During an <i>In Vitro<\/i> Fertilization Program"],"prefix":"10.1111","volume":"43","author":[{"given":"L.","family":"UNKILA\u2010KALLIO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"VUORELA\u2010VEPS\u00c4L\u00c4INEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"TIITINEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"HALMESM\u00c4KI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"YLIKORKALA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430105.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430105.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2000.430105.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T14:05:54Z","timestamp":1698588354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2000.430105.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1111\/j.8755-8920.2000.430105.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2000.430105.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}