{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:44Z","timestamp":1791158444038,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3041,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>PROBLEM: Uterine infection occurs in as much as 20% of preterm labor and results in increased decidual cytokines. The objective of this study was to examine the effect of interleukin\u20101 (IL\u20101) and the cyclooxygenase\u20102 (COX\u20102) inhibitor, NS\u2010398, on myometrial prostaglandin (PG) production and COX\u20102 expression.\u2028 METHOD OF STUDY: Human uterine myocytes were stimulated with IL\u20101 (0\u201350 ng\/mL) over 24 hr. PGE<jats:sub>2<\/jats:sub>, PGF<jats:sub>2\u03b1<\/jats:sub>, \nand 6\u2010keto F<jats:sub>1\u03b1<\/jats:sub> were measured by enzyme\u2010linked immunosorbent assay. Both COX\u20101 and COX\u20102 proteins and mRNA were measured by western and northern blot, respectively.\u2028 RESULTS: IL\u20101 increased PG production beginning at 6 hr. COX\u20102 protein increased beginning at 4 hr and continued to increase at 24 hr. COX\u20102 mRNA increased at 2 hr and peaked at 4 hr. NS\u2010398 blocked PG production but had no effect on COX\u20102 protein or mRNA.\u2028 CONCLUSIONS: IL\u20101 increases PG production by myometrium by increased COX\u20102 expression. NS\u2010398 completely blocks IL\u20101\u2010induced PG production. With intrauterine infection, IL\u20101 may induce labor through the autocrine production of uterotonic PGs.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2000.430304.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:54:05Z","timestamp":1071662045000},"page":"152-159","source":"Crossref","is-referenced-by-count":97,"title":["Interleukin\u20101 Stimulates Human Uterine Prostaglandin Production Through Induction of Cyclooxygenase\u20102 Expression"],"prefix":"10.1111","volume":"43","author":[{"given":"PHILLIP N.","family":"RAUK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JYE\u2010PING","family":"CHIAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430304.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430304.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2000.430304.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:03:58Z","timestamp":1698581038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2000.430304.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1111\/j.8755-8920.2000.430304.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2000.430304.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}