{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:42:41Z","timestamp":1698644561493},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3041,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>PROBLEM: The molecular basis of allo\u2010reactivity in reproductive immunity has not been fully clarified.\u2028 METHOD OF STUDY: Cytotoxic T lymphocytes (CTLs) were established from tumor\u2010infiltrating lymphocytes (TILs). The allo\u2010reactivity of the CTLs against various tumor cell lines or human leukocyte antigen (HLA)\u2010A allele\u2010transfected COS\u20107 cells was measured by Cr\u2010release or interferon\u2010\u0393 production assay.\u2028 RESULTS AND CONCLUSIONS: We have established CTLs reacting to an HLA\u2010A0206 molecule that matched a spouse's HLA\u2010A allele from the TILs of a 68\u2010year\u2010old multiparous patient with gastric cancer. The amino acids at positions 66 and 88 in the \u03b11 domain of HLA\u2010A0206, both of which were common in the other HLA\u2010A2 subtypes, were involved in the recognition by the CTLs. Endogenous peptides in the groove were not involved in the recognition. These results suggest the presence of long\u2010lasting memory CTLs raised by the reproduction process, and may facilitate a better understanding of the molecular basis of allo\u2010recognition during reproduction.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2000.430306.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:54:05Z","timestamp":1071662045000},"page":"167-173","source":"Crossref","is-referenced-by-count":0,"title":["Establishment and Epitope Analysis of Allo\u2010Specific Cytotoxic T Lymphocytes at a Tumor Site Recognizing a Spouse's HLA\u2010A0206 Molecule"],"prefix":"10.1111","volume":"43","author":[{"given":"NAOKO","family":"SEKI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AKIRA","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUICHI","family":"SUEFUJI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKASHI","family":"MINE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHOKO","family":"TANAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIN\u2010YA","family":"GOMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NOBUTOSHI","family":"KAWAGOE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIKUO","family":"KOUFUJI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KYOGO","family":"ITOH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430306.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430306.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2000.430306.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:03:53Z","timestamp":1698581033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2000.430306.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1111\/j.8755-8920.2000.430306.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2000.430306.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}