{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:48:33Z","timestamp":1759042113471},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3041,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>PROBLEM: Are cell adhesion molecules involved in the murine model of immunologically\u2010mediated spontaneous abortion?\u2028 METHOD OF STUDY: Pregnant CBA\/J female mice mated with DBA\/2 male mice were injected with monoclonal antibodies (MAbs) to intercellular adhesion molecule\u20101 (ICAM\u20101) and leukocyte function\u2010associate antigen\u20101 (LFA\u20101). On day 13 of gestation, viable and resorbed embryos were counted. Natural killer (NK) cell activity in the spleen, mixed lymphocyte reactions (MLR), mixed lymphocyte\u2010placenta reactions (MLPR), and levels of interferon (IFN)\u2010\u0393 were assayed.\u2028 RESULTS: Significant suppression of fetal resorption was observed by the injection of MAb to ICAM\u20101 and LFA\u20101. NK cell activity and the MLR anti\u2010(CBA\/J\u00d7DBA\/2)F1 were reduced in the antibody\u2010treated CBA\/J spleen. Moreover, the level of IFN\u2010\u0393 was significantly lower in the MLPR supernatants from the antibody\u2010treated group than those of the control group.\u2028 CONCLUSIONS: One mechanism in the murine model of spontaneous abortion may be through the interaction of cell adhesion molecules, which may modulate NK cell activities and cytokine production.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2000.430308.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:54:05Z","timestamp":1071662045000},"page":"180-185","source":"Crossref","is-referenced-by-count":7,"title":["Preventive Effect of Monoclonal Antibodies to Intercellular Adhesion Molecule\u20101 and Leukocyte Function\u2010Associate Antigen\u20101 on Murine Spontaneous Fetal Resorption"],"prefix":"10.1111","volume":"43","author":[{"given":"TOSHIYUKI","family":"TAKESHITA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MISAO","family":"SATOMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGEO","family":"AKIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TSUTOMU","family":"ARAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOKO","family":"NAKAGAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEMI","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430308.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.430308.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2000.430308.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:04:02Z","timestamp":1698581042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2000.430308.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1111\/j.8755-8920.2000.430308.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2000.430308.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}