{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:56:54Z","timestamp":1783702614038,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T00:00:00Z","timestamp":1071619200000},"content-version":"vor","delay-in-days":1141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p>PROBLEM: To aim of the study was to investigate whether controlled ovarian hyperstimulation (COH) causes endothelial activation and whether there is a correlation between endothelial activation and serum sex\u2010steroid levels.\u2028 METHOD OF STUDY: The study population consisted of 14 consecutive patients undergoing our routine IVF long gonadotropin\u2010releasing hormone\u2010analog protocol. Blood was drawn three times during the COH cycle: (1) day when adequate suppression was obtained (Day\u2010S); (2) on the day of or the day prior to hCG administration (Day\u2010hCG); and (3) on the day of ovum pick\u2010up (Day\u2010OPU). The levels of sex steroids and plasma soluble endothelial (E)\u2010selectin were compared among the time points. Soluble E\u2010selectin was measured with a commercial sandwich enzyme\u2010linked immunosorbent assay.\u2028 RESULTS: Soluble E\u2010selectin levels were significantly higher on Day\u2010OPU than Day\u2010S and Day\u2010hCG, whereas no difference was observed between Day\u2010hCG and Day\u2010S. No significant correlations were found between soluble E\u2010selectin level and patient age, number of gonadotropin ampoules used, number of oocytes retrieved, or serum estradiol, progesterone and human chorionic gonadotropin levels.\u2028 CONCLUSIONS: Human chorionic gonadotropin administration leads to endothelial activation regardless of the degree of ovarian response. Further studies are required to elucidate the relationship between COH and endothelial activation. These findings may lead to new strategies for predicting and preventing complications of COH, such as severe ovarian hyperstimulation syndrome.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2000.440501.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:55:44Z","timestamp":1071662144000},"page":"257-260","source":"Crossref","is-referenced-by-count":10,"title":["Controlled Ovarian Hyperstimulation \u2013 A State of Endothelial Activation1"],"prefix":"10.1111","volume":"44","author":[{"given":"RAOUL","family":"ORVIETO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARIELA","family":"SCHWARTZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ITAI","family":"BAR\u2010HAVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONIT","family":"ABIR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JACOB","family":"ASHKENAZI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTONIO","family":"LA\u2010MARCA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZION","family":"BEN\u2010RAFAEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,17]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.440501.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.440501.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2000.440501.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T13:58:22Z","timestamp":1698587902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2000.440501.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1111\/j.8755-8920.2000.440501.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2000.440501.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}