{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:09:36Z","timestamp":1746504576065},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T00:00:00Z","timestamp":1071619200000},"content-version":"vor","delay-in-days":1141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p>PROBLEM: The preconceptional natural\u2010killer cell (NK) activity predicts subsequent miscarriage among women with unexplained recurrent spontaneous abortion (RSA). Psycho\u2010neuro\u2010immuno\u2010endocrine network has recently been proposed as a mechanism for abortions. We therefore examined which psychosocial factors influenced the NK activity among women with RSA.\u2028 METHOD OF STUDY: We measured the preconceptional NK activity of 61 women with a history two consecutive unexplained first\u2010trimester miscarriages and no live births. We also administered semi\u2010structured interviews and a battery of self\u2010report questionnaires to assess their social support, personality, self\u2010esteem and psychiatric symptoms.\u2028 RESULTS: The preconceptional NK activity was negatively correlated with the women's neuroticism personality trait (r=\u22120.32, <jats:italic>P<\/jats:italic>=0.01) and current depressive symptoms (r=\u22120.26, <jats:italic>P<\/jats:italic>=0.05), and positively correlated with their self\u2010esteem (r=0.34, <jats:italic>P<\/jats:italic>=0.01).\u2028 CONCLUSIONS: In addition to several substances such as transforming\u2010growth\u2010factor beta and granulocyte\u2010macrophase colony\u2010stimulating factor, we found that low neuroticism, low depression scale score and high self\u2010esteem contributed to high NK activity among women with RSA.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2000.440509.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:55:44Z","timestamp":1071662144000},"page":"299-302","source":"Crossref","is-referenced-by-count":11,"title":["Psychosocial Factors Regulating Natural\u2010Killer Cell Activity in Recurrent Spontaneous Abortions"],"prefix":"10.1111","volume":"44","author":[{"given":"SHIRO","family":"HORI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUMI","family":"NAKANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIAKI A.","family":"FURUKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAYUMI","family":"OGASAWARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KINUE","family":"KATANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KOJI","family":"AOKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHINORI","family":"KITAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,17]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.440509.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2000.440509.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2000.440509.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T13:58:25Z","timestamp":1698587905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2000.440509.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1111\/j.8755-8920.2000.440509.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2000.440509.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}