{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:27:14Z","timestamp":1761596834529},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T00:00:00Z","timestamp":1071619200000},"content-version":"vor","delay-in-days":868,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>PROBLEM: How do major histocompatibility complex (MHC) I positive\/negative choriocarcinoma (CC) cells affect the production of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interferon\u2010\u03b3 (IFN\u2010\u03b3), interleukin\u201010 (IL\u201010), interleukin\u20104 (IL\u20104), and granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF) by decidual CD56<jats:sup>++<\/jats:sup> cells (large granular lymphocytes [LGL]), LGL\u2010depleted decidual cells (WASH) and unseparated decidual cells (DEC) in cocultures?\u2028METHOD OF STUDY: Decidual tissue was obtained by legal abortions. CD 56<jats:sup>++<\/jats:sup> LGL were isolated in a magnetic cell separator. Cytokines were measured by ELISA. Differences were analyzed for significance by Wilcoxons test. \u2028RESULTS: We found a significant increase of IL\u201010 in LGL\/JEG\u20103 and of TNF\u2010\u03b1 in LGL\/JAR cocultures compared to noncocultured decidual cells. There was a significant increase of IL\u201010 and TNF\u2010\u03b1 and a significant decrease of GM\u2010CSF in WASH and DEC cocultures with both JEG\u20103 and JAR. IFN\u2010\u03b3 was only found in 3\/11 cases of LGL\/JAR cocultures. No IL\u20104 was found in any experiment. \u2028CONCLUSION: MHC class I positive\/negative CC modulate the cytokine production of decidual LGL in different ways.<\/jats:p>","DOI":"10.1111\/j.8755-8920.2001.460204.x","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T11:59:36Z","timestamp":1071662376000},"page":"137-143","source":"Crossref","is-referenced-by-count":22,"title":["Choriocarcinoma Cells Modulate the Cytokine Production of Decidual Large Granular Lymphocytes in Coculture"],"prefix":"10.1111","volume":"46","author":[{"given":"Lorenz","family":"Rieger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"K\u00e4mmerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"S\u00fctterlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Dietl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,17]]},"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.8755-8920.2001.460204.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.8755-8920.2001.460204.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:18:35Z","timestamp":1700417915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.8755-8920.2001.460204.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1111\/j.8755-8920.2001.460204.x"],"URL":"https:\/\/doi.org\/10.1111\/j.8755-8920.2001.460204.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}