{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:46:51Z","timestamp":1791017211110,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T00:00:00Z","timestamp":1381708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T00:00:00Z","timestamp":1381708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Quadro deRefer\u00eancia Estrat\u00e9gico Nacional","award":["2008\/1448"],"award-info":[{"award-number":["2008\/1448"]}]},{"name":"Sociedade Portuguesa de Alergologia e Imunologia Cl\u00ednica"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Appl Microbiol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1111\/jam.12296","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T10:49:07Z","timestamp":1372848547000},"page":"1411-1419","source":"Crossref","is-referenced-by-count":17,"title":["A diversity profile from the staphylococcal community on atopic dermatitis skin: a molecular approach"],"prefix":"10.1093","volume":"115","author":[{"given":"J.","family":"Soares","sequence":"first","affiliation":[{"name":"CBQF - School of Biotechnology; Portuguese Catholic University; Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Service and Laboratory of Immunology; Medicine School of Porto University; Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tavaria","sequence":"additional","affiliation":[{"name":"CBQF - School of Biotechnology; Portuguese Catholic University; Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Service and Laboratory of Immunology; Medicine School of Porto University; Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pintado","sequence":"additional","affiliation":[{"name":"CBQF - School of Biotechnology; Portuguese Catholic University; Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,14]]},"reference":[{"key":"10.1111\/jam.12296-BIB0001|jam12296-cit-0001","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/BF02507115","article-title":"Prevalence of producers of enterotoxins and toxic shock syndrome toxin-1 among Staphylococcus aureus strains isolated from atopic dermatitis lesions","volume":"288","author":"Akiyama","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/jam.12296-BIB0002|jam12296-cit-0002","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1046\/j.1365-2249.2001.01620.x","article-title":"Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD52 B lymphocytes without an increase in disease severity","volume":"125","author":"Arkwright","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/jam.12296-BIB0003|jam12296-cit-0003","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/JCM.01734-07","article-title":"Pulsed-Field gel electrophoresis of Staphylococcus aureus isolates from atopic patients revealing presence of similar strains in isolates from children and their parents","volume":"46","author":"Bonness","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1111\/jam.12296-BIB0150|jam12296-cit-0150","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1034\/j.1398-9995.2000.00432.x","article-title":"Severe atopic dermatitis is associated with sensitisation to staphylococcal enterotoxin B (SEB)","volume":"55","author":"Breuer","year":"2000","journal-title":"Allergy"},{"key":"10.1111\/jam.12296-BIB0004|jam12296-cit-0004","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1067\/mai.2000.105528","article-title":"Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis","volume":"105","author":"Bunikowski","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/jam.12296-BIB0005|jam12296-cit-0005","first-page":"22","article-title":"Study on superantigen production by Staphylococcus aureus colonizing in skin lesion and its clinical significance in the patients with atopic dermatitis and eczema","volume":"34","author":"Chen","year":"2005","journal-title":"J Clin Dermatol"},{"key":"10.1111\/jam.12296-BIB0006|jam12296-cit-0006","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1067\/mai.2001.117455","article-title":"Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin","volume":"108","author":"Cho","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/jam.12296-BIB0007|jam12296-cit-0007","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2133.2008.08437.x","article-title":"Skin microbiota: a source of disease or defence?","volume":"158","author":"Cogen","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/jam.12296-BIB0008|jam12296-cit-0008","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000250099","article-title":"On the resident aerobic bacterial skin flora in unaffected skin of patients with atopic dermatitis and in healthy controls","volume":"164","author":"Gloor","year":"1982","journal-title":"Dermatologica"},{"key":"10.1111\/jam.12296-BIB0009|jam12296-cit-0009","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1171700","article-title":"Topographical and temporal diversity of the human skin microbiome","volume":"324","author":"Grice","year":"2009","journal-title":"Science"},{"key":"10.1111\/jam.12296-BIB0010|jam12296-cit-0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"92","author":"Hanifin","year":"1980","journal-title":"Acta Derm-Venereol"},{"key":"10.1111\/jam.12296-BIB0012|jam12296-cit-0012","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000249493","article-title":"Staphylococcus aureus skin colonization in atopic dermatitis patients","volume":"170","author":"Hauser","year":"1985","journal-title":"Dermatologica"},{"key":"10.1111\/jam.12296-BIB0013|jam12296-cit-0013","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/infdis\/165.6.1064","article-title":"Staphylococcal skin colonization in children with atopic dermatitis: prevalence, persistence, and transmission of toxigenic and nontoxigenic strains","volume":"165","author":"Hoeger","year":"1992","journal-title":"J Infect Dis"},{"key":"10.1111\/jam.12296-BIB0014|jam12296-cit-0014","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijfoodmicro.2007.02.013","article-title":"Novel multiplex PCR for the detection of the Staphylococcus aureus superantigen and its application to raw meat isolates in Korea","volume":"117","author":"Hwang","year":"2007","journal-title":"Int J Food Microbiol"},{"key":"10.1111\/jam.12296-BIB0015|jam12296-cit-0015","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1099\/jmm.0.47235-0","article-title":"Development of a real-time PCR assay for the detection and identification of Staphylococcus capitis, Staphylococcus haemolyticus and Staphylococcus warneri","volume":"56","author":"Iwase","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1111\/jam.12296-BIB0016|jam12296-cit-0016","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature09074","article-title":"Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization","volume":"465","author":"Iwase","year":"2010","journal-title":"Nature"},{"key":"10.1111\/jam.12296-BIB0017|jam12296-cit-0017","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1101\/gr.131029.111","article-title":"Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis","volume":"22","author":"Kong","year":"2012","journal-title":"Genome Res"},{"key":"10.1111\/jam.12296-BIB0018|jam12296-cit-0018","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2958.2006.05540.x","article-title":"The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci","volume":"63","author":"Lai","year":"2007","journal-title":"Mol Microbiol"},{"key":"10.1111\/jam.12296-BIB0019|jam12296-cit-0019","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1038\/jid.2010.123","article-title":"Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections","volume":"130","author":"Lai","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/jam.12296-BIB0020|jam12296-cit-0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(03)12193-9","article-title":"Atopic dermatitis","volume":"361","author":"Leung","year":"2003","journal-title":"Lancet"},{"key":"10.1111\/jam.12296-BIB0021|jam12296-cit-0021","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2133.1974.tb06447.x","article-title":"Staphylococcus aureus in the lesions of atopic dermatitis","volume":"90","author":"Leyden","year":"1974","journal-title":"Br J Dermatol"},{"key":"10.1111\/jam.12296-BIB0022|jam12296-cit-0022","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1073\/pnas.0702159104","article-title":"Gram-positive three-component antimicrobial peptide-sensing system","volume":"104","author":"Li","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jam.12296-BIB0023|jam12296-cit-0023","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12016-007-0044-5","article-title":"Role of bacterial pathogens in atopic dermatitis","volume":"33","author":"Lin","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1111\/jam.12296-BIB0024|jam12296-cit-0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5070\/D35HX776QP","article-title":"Atopic dermatitis, innate immunity, and infection","volume":"17","author":"Lopes","year":"2011","journal-title":"Dermatol Online J"},{"key":"10.1111\/jam.12296-BIB0025|jam12296-cit-0025","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1128\/JCM.42.8.3869-3872.2004","article-title":"Modified multiplex PCR method for detection of pyrogenic exotoxin genes in staphylococcal isolates","volume":"42","author":"L\u00f8vseth","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1111\/jam.12296-BIB0026|jam12296-cit-0026","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/JCM.34.12.2888-2893.1996","article-title":"Species-specific and ubiquitous DNA-based assays for rapid identification of Staphylococcus epidermidis","volume":"34","author":"Martineau","year":"1996","journal-title":"J Clin Microbiol"},{"key":"10.1111\/jam.12296-BIB0027|jam12296-cit-0027","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1099\/00221287-146-7-1535","article-title":"The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis","volume":"146","author":"McCrea","year":"2000","journal-title":"Microbiology"},{"key":"10.1111\/jam.12296-BIB0028|jam12296-cit-0028","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1128\/JCM.38.3.1032-1035.2000","article-title":"Multiplex PCR for detection of genes for Staphylococcus aureus enterotoxins, exfoliative toxins, toxic shock syndrome toxin 1, and methicillin resistance","volume":"38","author":"Mehrotra","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1111\/jam.12296-BIB0029|jam12296-cit-0029","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10096-003-0928-0","article-title":"High prevalence of superantigens associated with the egc locus in Staphylococcus aureus isolates from patients with atopic eczema","volume":"22","author":"Mempel","year":"2003","journal-title":"Eur J Clin Microbiol"},{"key":"10.1111\/jam.12296-BIB0030|jam12296-cit-0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijid.2011.09.014","article-title":"Skin colonization by superantigen-producing Staphylococcus aureus in Egyptian patients with atopic dermatitis and its relation to disease severity and serum interleukin-4 level","volume":"16","author":"Nada","year":"2012","journal-title":"Int J Infect Dis"},{"key":"10.1111\/jam.12296-BIB0031|jam12296-cit-0031","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1128\/IAI.66.6.2666-2673.1998","article-title":"A fibrinogen-binding protein of Staphylococcus epidermidis","volume":"66","author":"Nilsson","year":"1998","journal-title":"Infect Immun"},{"key":"10.1111\/jam.12296-BIB0032|jam12296-cit-0032","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/030006059702500305","article-title":"Staphylococcus aureus in the anterior nares and subungual spaces of the hands in atopic dermatitis","volume":"27","author":"Nishijina","year":"1997","journal-title":"J Int Med Res"},{"key":"10.1111\/jam.12296-BIB0033|jam12296-cit-0033","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1056\/NEJMoa021481","article-title":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis","volume":"347","author":"Ong","year":"2002","journal-title":"New Engl J Med"},{"key":"10.1111\/jam.12296-BIB0034|jam12296-cit-0034","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1111\/jam.12296-BIB0035|jam12296-cit-0035","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.193.9.1067","article-title":"Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine","volume":"193","author":"Peschel","year":"2001","journal-title":"J Exp Med"},{"key":"10.1111\/jam.12296-BIB0036|jam12296-cit-0036","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00130832-200410000-00008","article-title":"Microbial colonization and atopic dermatitis","volume":"4","author":"Roll","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1111\/jam.12296-BIB0037|jam12296-cit-0037","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.meegid.2011.03.022","article-title":"Skin microbiota: microbial community structure and its potential association with health and disease","volume":"11","author":"Rosenthal","year":"2011","journal-title":"Infect Genet Evol"},{"key":"10.1111\/jam.12296-BIB0038|jam12296-cit-0038","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng2020","article-title":"Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema","volume":"39","author":"Sandilands","year":"2007","journal-title":"Nat Genet"},{"key":"10.1111\/jam.12296-BIB0039|jam12296-cit-0039","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1086\/586746","article-title":"Superantigen profile of Staphylococcus aureus isolates from patients with steroid-resistant atopic dermatitis","volume":"46","author":"Schlievert","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1111\/jam.12296-BIB0040|jam12296-cit-0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1574-695X.2008.00387.x","article-title":"Multiplex PCR assay to identify methicillin-resistant Staphylococcus haemolyticus","volume":"52","author":"Schuenck","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1111\/jam.12296-BIB0041|jam12296-cit-0041","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1128\/AAC.48.12.4673-4679.2004","article-title":"Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases","volume":"48","author":"Sieprawska-Lupa","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/jam.12296-BIB0042|jam12296-cit-0042","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/j.1468-3083.2006.01748.x","article-title":"Influence of narrow-band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis","volume":"20","author":"Silva","year":"2006","journal-title":"J Eur Acad Dermatol"},{"key":"10.1111\/jam.12296-BIB0043|jam12296-cit-0043","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijfoodmicro.2011.02.008","article-title":"Biodiversity and characterization of Staphylococcus species isolated from a small manufacturing dairy plant in Portugal","volume":"146","author":"Soares","year":"2011","journal-title":"Int J Food Microbiol"},{"key":"10.1111\/jam.12296-BIB0044|jam12296-cit-0044","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1365-2672.2012.05274.x","article-title":"Chitosan: antimicrobial action upon staphylococci after impregnation onto cotton fabric","volume":"112","author":"Tavaria","year":"2012","journal-title":"J Appl Microbiol"},{"key":"10.1111\/jam.12296-BIB0045|jam12296-cit-0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0923-2508(99)80030-8","article-title":"Molecular characterization of femA from Staphylococcus hominis and Staphylococcus saprophyticus, and femA-based discrimination of staphylococcal species","volume":"150","author":"Vannuffel","year":"1999","journal-title":"Res Microbiol"},{"key":"10.1111\/jam.12296-BIB0046|jam12296-cit-0046","doi-asserted-by":"crossref","first-page":"6805","DOI":"10.1128\/IAI.70.12.6805-6810.2002","article-title":"Identification of a fibronectin-binding protein from Staphylococcus epidermidis","volume":"70","author":"Williams","year":"2002","journal-title":"Infect Immun"},{"key":"10.1111\/jam.12296-BIB0047|jam12296-cit-0047","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1365-2222.2004.1687.x","article-title":"Presence of staphylococcal exfoliative toxin A in sera of patients with atopic dermatitis","volume":"34","author":"Yagi","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1111\/jam.12296-BIB0200|jam12296-cit-0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.micpath.2006.01.001","article-title":"Role of several Staphylococcus aureus virulence factors on the inflammatory response in bovine mammary gland","volume":"40","author":"Zecconi","year":"2006","journal-title":"Microb Pathogenesis"},{"key":"10.1111\/jam.12296-BIB0049|jam12296-cit-0049","first-page":"123","article-title":"Study of erythroderma and psoriasis exacerbation by staphylococcal superantigens","volume":"7","author":"Zuel-Fakkar","year":"2010","journal-title":"J Egypt Women Dermatol Soc"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjam.12296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjam.12296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jam.12296\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T21:15:55Z","timestamp":1688332555000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/115\/6\/1411\/6716526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,14]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"URL":"https:\/\/doi.org\/10.1111\/jam.12296","archive":["Portico"],"relation":{},"ISSN":["1364-5072"],"issn-type":[{"value":"1364-5072","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,14]]}}}