{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:46:55Z","timestamp":1776217615284,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":544,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405033\/2016-8"],"award-info":[{"award-number":["405033\/2016-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["501979\/2014-0"],"award-info":[{"award-number":["501979\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/19574-5"],"award-info":[{"award-number":["2015\/19574-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Allergic asthma is a chronic inflammatory lung disease characterized by a Th2-type immune response pattern. The development of nonspecific immunotherapy is one of the primary goals for the control of this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>In this study, we evaluated the therapeutic effects of Lactococcus lactis-producing mycobacterial heat shock protein 65 (LLHsp65) in an ovalbumin (OVA)-induced allergic asthma model. OVA-challenged BALB\/c mice were orally administrated with LLHsp65 for 10 consecutive days. The results demonstrate that LLhsp65 attenuates critical features of allergic inflammation, like airway hyperresponsiveness and mucus production. Likewise, the treatment decreases the pulmonary eosinophilia and the serum level of OVA-specific IgE. In addition to deviating immune responses towards Th1-cytokine profile, increase regulatory T cells, and cytokine levels, such as IL-6 and IL-10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results reveal that the mucosal immunotherapy of LLHsp65 significantly reduces the overall burden of airway allergic inflammation, suggesting a promising therapeutic strategy for allergic asthma treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance and Impact of the Study<\/jats:title>\n                    <jats:p>This research reveals new perspectives on nonspecific immunotherapy based on the delivery of recombinant proteins by lactic acid bacteria to treat of allergic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jam.14913","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T22:19:00Z","timestamp":1604009940000},"page":"2075-2086","source":"Crossref","is-referenced-by-count":6,"title":["Oral administration of Hsp65-producing Lactococcus lactis attenuates allergic asthma in a murine model"],"prefix":"10.1093","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-348X","authenticated-orcid":false,"given":"L.B.","family":"de Lacerda","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.M.","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-8345","authenticated-orcid":false,"given":"A.P.","family":"Masson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.T.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6280-0714","authenticated-orcid":false,"given":"M.C.","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-5294","authenticated-orcid":false,"given":"L.N.Z.","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.R.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-8993","authenticated-orcid":false,"given":"A.","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Ecology, Genetics and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil Institute of Biological SciencesFederal University of Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-4568","authenticated-orcid":false,"given":"C.L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"2026041420250280800_jam14913-bib-0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109461","article-title":"Genetically engineered Lactococcus \u00a0lactis protect against house dust mite allergy in a BALB\/c mouse model","volume":"9","author":"Ai","year":"2014","journal-title":"PLoS One"},{"key":"2026041420250280800_jam14913-bib-0002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2567.2001.01235.x","article-title":"Mechanisms of interleukin-10-mediated immune suppression","volume":"103","author":"Akdis","year":"2001","journal-title":"Immunology"},{"key":"2026041420250280800_jam14913-bib-0003","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jaci.2005.09.004","article-title":"T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases","volume":"116","author":"Akdis","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"2026041420250280800_jam14913-bib-0004","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jaci.2015.07.007","article-title":"New and future strategies to improve asthma control in children","volume":"136","author":"Anderson","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2026041420250280800_jam14913-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/725719","article-title":"Mucosal immunity and sublingual immunotherapy in respiratory disorders","volume":"2012","author":"Bahceciler","year":"2012","journal-title":"J Allergy"},{"key":"2026041420250280800_jam14913-bib-0006","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4161\/hv.5.4.7553","article-title":"Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins","volume":"5","author":"Berm\u00fadez-Humar\u00e1n","year":"2009","journal-title":"Hum Vaccin"},{"issue":"Suppl 1","key":"2026041420250280800_jam14913-bib-0007","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2859-10-S1-S4","article-title":"Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines","volume":"10","author":"Berm\u00fadez-Humar\u00e1n","year":"2011","journal-title":"Microb Cell Fact"},{"key":"2026041420250280800_jam14913-bib-0008","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.4049\/jimmunol.1401417","article-title":"Functions of heat shock proteins in pathways of the innate and adaptive immune system","volume":"193","author":"Binder","year":"2014","journal-title":"J Immunol"},{"issue":"1","key":"2026041420250280800_jam14913-bib-0053","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.resp.2013.07.005","article-title":"Allergen challenge during halothane compared to isoflurane anesthesia induces a more potent peripheral lung response","volume":"189","author":"Borges","year":"2013","journal-title":"Respiratory Physiology & Neurobiology"},{"key":"2026041420250280800_jam14913-bib-0009","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"Asthma: From bronchoconstriction to airways inflammation and remodeling","volume":"161","author":"Bousquet","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2026041420250280800_jam14913-bib-0010","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/02770903.2015.1020386","article-title":"What lies beyond asthma control test: suggestions for clinical practice","volume":"53","author":"Caminati","year":"2016","journal-title":"J Asthma"},{"key":"2026041420250280800_jam14913-bib-0011","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jaci.2007.03.023","article-title":"Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties","volume":"119","author":"Debarry","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"2026041420250280800_jam14913-bib-0052","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4238\/2012.April.27.14","article-title":"Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65-kDa heat shock protein in Lactococcus lactis","volume":"11","author":"De Azevedo","year":"2012","journal-title":"Genetics and Molecular Research"},{"issue":"7","key":"2026041420250280800_jam14913-bib-0050","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/icb.2011.9","article-title":"IFN-\u03b3-mediated efficacy of allergen-free immunotherapy using mycobacterial antigens and CpG-ODN","volume":"89","author":"Fonseca","year":"2011","journal-title":"Immunology & Cell Biology"},{"issue":"12","key":"2026041420250280800_jam14913-bib-0051","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1128\/IAI.00580-09","article-title":"Mycobacterium tuberculosis Culture Filtrate Proteins plus CpG Oligodeoxynucleotides Confer Protection to Mycobacterium bovis BCG-Primed Mice by Inhibiting Interleukin-4 Secretion","volume":"77","author":"Fonseca","year":"2009","journal-title":"Infection and Immunity"},{"key":"2026041420250280800_jam14913-bib-0012","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2222.2011.03845.x","article-title":"Recombinant DNA immunotherapy ameliorate established airway allergy in a IL-10 dependent pathway","volume":"42","author":"Fonseca","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"2026041420250280800_jam14913-bib-0013","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/all.12555","article-title":"Requirement of MyD88 and Fas pathways for the efficacy of allergen-free immunotherapy","volume":"70","author":"Fonseca","year":"2015","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"2026041420250280800_jam14913-bib-0014","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2217\/imt.14.63","article-title":"Nanoparticle based-immunotherapy against allergy","volume":"6","author":"Gamazo","year":"2014","journal-title":"Immunotherapy"},{"key":"2026041420250280800_jam14913-bib-0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2015.00269","article-title":"Luminal conversion and immunoregulation by probiotics","volume":"6","author":"Ganesh","year":"2015","journal-title":"Front Pharmacol"},{"key":"2026041420250280800_jam14913-bib-0016","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00030","article-title":"Hsp65-producing Lactococcus lactis prevents inflammatory intestinal disease in mice by IL-10- and TLR2-dependent pathways","volume":"8","author":"Gomes-Santos","year":"2017","journal-title":"Front Immunol"},{"key":"2026041420250280800_jam14913-bib-0017","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10875-010-9375-8","article-title":"Differential suppression of heat-killed lactobacilli isolated from kimchi, a Korean traditional food, on airway hyper-responsiveness in mice","volume":"30","author":"Hong","year":"2010","journal-title":"J Clin Immunol"},{"key":"2026041420250280800_jam14913-bib-0018","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4168\/aair.2012.4.3.150","article-title":"Asthma prevention by Lactobacillus rhamnosus in a mouse model is associated with CD4(+)CD25(+)Foxp3(+) T cells","volume":"4","author":"Jang","year":"2012","journal-title":"Allergy Asthma Immunol Res"},{"key":"2026041420250280800_jam14913-bib-0019","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4168\/aair.2016.8.3.191","article-title":"Allergen immunotherapy: past, present, and future","volume":"8","author":"Jutel","year":"2016","journal-title":"Allergy Asthma Immunol Res"},{"key":"2026041420250280800_jam14913-bib-0020","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1073\/pnas.0904055107","article-title":"Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders","volume":"107","author":"Kwon","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026041420250280800_jam14913-bib-0021","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2014","journal-title":"Nat Immunol"},{"key":"2026041420250280800_jam14913-bib-0022","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.intimp.2012.10.025","article-title":"Induced apoptosis of Th2 lymphocytes and inhibition of airway hyperresponsiveness and inflammation by combined lactic acid bacteria treatment","volume":"15","author":"Lin","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"2026041420250280800_jam14913-bib-0023","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.imlet.2016.04.008","article-title":"Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice","volume":"174","author":"Liu","year":"2016","journal-title":"Immunol Lett"},{"key":"2026041420250280800_jam14913-bib-0024","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1757-4749-6-33","article-title":"Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis","volume":"6","author":"Luerce","year":"2014","journal-title":"Gut Pathog"},{"key":"2026041420250280800_jam14913-bib-0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1365-2222.2009.03437.x","article-title":"Bacterial strain-specific induction of Foxp3 + T regulatory cells is protective in murine allergy models","volume":"40","author":"Lyons","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"2026041420250280800_jam14913-bib-0026","first-page":"1","article-title":"Oral administration of recombinant Lactococcus lactis expressing HSP65 and tandemly repeated P277 reduces the incidence of type I diabetes in non-obese diabetic mice","volume":"9","author":"Ma","year":"2014","journal-title":"PLoS One"},{"key":"2026041420250280800_jam14913-bib-0027","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1365-2222.2010.03502.x","article-title":"An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model","volume":"40","author":"Marinho","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"2026041420250280800_jam14913-bib-0028","first-page":"1","article-title":"Immunomodulatory activity of Lactococcus lactis A17 from Taiwan fermented cabbage in OVA-sensitized BALB\/c mice\u2019, evidence-based complement","volume":"2013","author":"Mei","year":"2012","journal-title":"Altern Med"},{"key":"2026041420250280800_jam14913-bib-0029","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm0602-567","article-title":"The role of Th1\/Th2 polarization in mucosal immunity","volume":"8","author":"Neurath","year":"2002","journal-title":"Nat Med"},{"key":"2026041420250280800_jam14913-bib-0030","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000109294","article-title":"Antiallergic effects of Lactobacillus pentosus strain S-PT84 mediated by modulation of Th1\/Th2 immunobalance and induction of IL-10 production","volume":"145","author":"Nonaka","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"2026041420250280800_jam14913-bib-0031","doi-asserted-by":"crossref","first-page":"411S","DOI":"10.1378\/chest.123.3_suppl.411S","article-title":"Airway hyperresponsiveness","volume":"123","author":"O\u2019Byrne","year":"2003","journal-title":"Chest"},{"key":"2026041420250280800_jam14913-bib-0032","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2249.2010.04109.x","article-title":"Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data","volume":"160","author":"Ozdemir","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"2026041420250280800_jam14913-bib-0033","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/cea.12564","article-title":"Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR9-dependent IFN-??-CCR2 signalling circuit","volume":"45","author":"Prado","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"2026041420250280800_jam14913-bib-0034","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.it.2010.11.001","article-title":"The HSP60 immune system network","volume":"32","author":"Quintana","year":"2011","journal-title":"Trends Immunol"},{"key":"2026041420250280800_jam14913-bib-0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2012.07.012","article-title":"Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells","volume":"40","author":"Rezende","year":"2013","journal-title":"J Autoimmun"},{"key":"2026041420250280800_jam14913-bib-0036","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.4049\/jimmunol.169.9.5300","article-title":"Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness","volume":"169","author":"Rha","year":"2002","journal-title":"J Immunol"},{"key":"2026041420250280800_jam14913-bib-0037","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaci.2003.11.025","article-title":"Immunologic influences on allergy and the TH1\/TH2 balance","volume":"113","author":"Romagnani","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"2026041420250280800_jam14913-bib-0038","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"2026041420250280800_jam14913-bib-0039","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim et Biophys Acta (BBA)"},{"key":"2026041420250280800_jam14913-bib-0040","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1084\/jem.20061401","article-title":"Interleukin-17 is a negative regulator of established allergic asthma","volume":"203","author":"Schnyder-Candrian","year":"2006","journal-title":"J Exp Med"},{"key":"2026041420250280800_jam14913-bib-0041","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.4049\/jimmunol.1201138","article-title":"\u2018Microbial heat shock protein 65 attenuates airway hyperresponsiveness and inflammation by modulating the function of dendritic cells","volume":"189","author":"Shin","year":"2012","journal-title":"J Immunol"},{"key":"2026041420250280800_jam14913-bib-0043","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri749","article-title":"Roles of heat-shock proteins in innate and adaptive immunity","volume":"2","author":"Srivastava","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2026041420250280800_jam14913-bib-0044","first-page":"1","article-title":"Th1\/Th2 balance: a natural therapeutic approach to Th2 polarization in allergy","author":"Sult","year":"2003","journal-title":"Appl Nutr Sci Rep"},{"key":"2026041420250280800_jam14913-bib-0045","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1152\/japplphysiol.00924.2003","article-title":"The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?","volume":"96","author":"Wagers","year":"2004","journal-title":"J Appl Physiol"},{"key":"2026041420250280800_jam14913-bib-0046","volume-title":"Asthma Fact Sheet","author":"WHO","year":"2017"},{"key":"2026041420250280800_jam14913-bib-0047","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.intimp.2005.09.010","article-title":"Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1\/Th2 balance in ovalbumin (OVA)-induced asthma model mice","volume":"6","author":"Wu","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"2026041420250280800_jam14913-bib-0048","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/cmi.2011.17","article-title":"Strategies of mucosal immunotherapy for allergic diseases","volume":"8","author":"Ye","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"2026041420250280800_jam14913-bib-0049","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4168\/aair.2010.2.3.199","article-title":"The effects of Lactobacillus rhamnosus on the prevention of asthma in a murine model","volume":"2","author":"Yu","year":"2010","journal-title":"Allergy Asthma Immunol Res"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jam.14913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jam.14913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/130\/6\/2075\/47353761\/jambio2075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/130\/6\/2075\/47353761\/jambio2075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:49:16Z","timestamp":1776214156000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/130\/6\/2075\/6715587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jam.14913","relation":{},"ISSN":["1365-2672","1364-5072"],"issn-type":[{"value":"1365-2672","type":"electronic"},{"value":"1364-5072","type":"print"}],"subject":[],"published-other":{"date-parts":[[2021,6,1]]},"published":{"date-parts":[[2021,6,1]]}}}