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Salmonella Dublin and S. Enteritidis (i) were internalized at the respective rates of 79\u00b76 and 65\u00b70% (P \u2264 0\u00b705) by U937 (human) macrophages, and 70\u00b74 and 66\u00b79% by HD11 (chicken) macrophages; and (ii) multiplied at the respective rates of 3\u00b72- and 2\u00b77-fold within U937 cells, and 1\u00b79- and 1\u00b71-fold (P \u2264 0\u00b705) within HD11 cells respectively. Seventy per cent of 10 S. Dublin strains stimulated IL-8 production, while 70% of S. Enteritidis strains enhanced production of IL-1\u03b2, IL-6, IL-8, IL-10, IL-12p70 and TNF in Caco-2 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with S. Enteritidis, S. Dublin had stronger ability to survive within macrophages and induced weak cytokine production, which may explain the higher incidence of invasive diseases caused by S. Dublin in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance and Impact of the STUDY<\/jats:title>\n                    <jats:p>This study compared S. enterica serovars Enteritidis and Dublin to provide comparative data about the profile of the two serovars in cells from humans, the common host and their respective natural animal hosts and vice versa in order to check the differences between these two phylogenetically closely related serovars that share antigenic properties but present different phenotypic behaviours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jam.14924","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T01:22:20Z","timestamp":1604539340000},"page":"2123-2131","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of cell invasion, macrophage survival and inflammatory cytokines profiles between Salmonella enterica serovars Enteritidis and Dublin from Brazil"],"prefix":"10.1093","volume":"130","author":[{"given":"F.","family":"Campioni","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto \u2013 USP, Departamento de An\u00e1lises Cl\u00ednicas Toxicol\u00f3gicas e Bromatol\u00f3gicas Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.N.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto \u2013 USP, Departamento de An\u00e1lises Cl\u00ednicas Toxicol\u00f3gicas e Bromatol\u00f3gicas Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.M.","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz \u2013 Centro de Laborat\u00f3rios Regionais \u2013 Ribeir\u00e3o Preto VI Laborat\u00f3rio de Microbiologia de Alimentos Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.P.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz \u2013 FIOCRUZ \u2013 Laborat\u00f3rio de Enterobact\u00e9rias Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Tiba-Casas","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz \u2013 Centro de Bacteriologia S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-9355","authenticated-orcid":false,"given":"J.P.","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto \u2013 USP, Departamento de An\u00e1lises Cl\u00ednicas Toxicol\u00f3gicas e Bromatol\u00f3gicas Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"2026041420250191900_jam14924-bib-0001","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2672.2010.04889.x","article-title":"Induction of cytokine formation by human intestinal bacteria in gut epithelial cell lines","volume":"110","author":"Bahrami","year":"2011","journal-title":"J Appl Microbiol"},{"key":"2026041420250191900_jam14924-bib-0002","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2180-9-237","article-title":"Genomic and phenotypic variation in epidemic-spanning Salmonella enterica serovar Enteritidis isolates","volume":"9","author":"Betancor","year":"2009","journal-title":"BMC Microbiol"},{"key":"2026041420250191900_jam14924-bib-0003","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1874285801206010005","article-title":"Genomic comparison of the closely related Salmonella 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