{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:37:08Z","timestamp":1792017428305,"version":"4.4.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR20281\/BBE\/117\/179\/2016"],"award-info":[{"award-number":["BT\/PR20281\/BBE\/117\/179\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Microbiology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1111\/jam.14985","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T05:56:59Z","timestamp":1609394219000},"page":"1072-1082","source":"Crossref","is-referenced-by-count":56,"title":["Therapeutic applications of lysostaphin against\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1093","volume":"131","author":[{"given":"J.","family":"Jayakumar","sequence":"first","affiliation":[{"name":"Center for Nanosciences and Molecular Medicine Amrita Vishwa Vidyapeetham Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.A.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Amrita Institute of Medical Sciences and Research CenterAmrita Vishwa Vidyapeetham Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Biswas","sequence":"additional","affiliation":[{"name":"Center for Nanosciences and Molecular Medicine Amrita Vishwa Vidyapeetham Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-0609","authenticated-orcid":false,"given":"R.","family":"Biswas","sequence":"additional","affiliation":[{"name":"Center for Nanosciences and Molecular Medicine Amrita Vishwa Vidyapeetham Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.02.009"},{"key":"e_1_2_8_3_1","first-page":"263","article-title":"Inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples","volume":"42","author":"Appalaraju B.","year":"2010","journal-title":"J Commun Dis"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11060356"},{"key":"e_1_2_8_5_1","first-page":"2474","article-title":"Management of Staphylococcus aureus infections","volume":"72","author":"Bamberger D.M.","year":"2005","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(06)72256-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-004-3106-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3041139"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481107700822"},{"key":"e_1_2_8_10_1","first-page":"8","article-title":"Mechanisms for linezolid\u2010induced anemia and thrombocytopenia","volume":"8","author":"Bernstein W.B.","year":"2003","journal-title":"Ann Pharmacother"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/652767"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00281.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtm.2015.21"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx437"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00507"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biori.2019.08.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13136"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2018.06.013"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1355"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-2915-x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2014-9074"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2010.509363"},{"key":"e_1_2_8_23_1","first-page":"1432","article-title":"Lysostaphin treatment of methicillin\u2010resistant Staphylococcus aureus keratitis in the rabbit","volume":"41","author":"Dajcs J.J.","year":"2000","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"e_1_2_8_24_1","first-page":"3712","article-title":"Immunity to lysostaphin and its therapeutic value for ocular MRSA infections in the rabbit","volume":"43","author":"Dajcs J.J.","year":"2002","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1188-z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.01.016"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2009.04472.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00135"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl539"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24162892"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S214521"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474651413500830"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw1228"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801013115"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.29.3.892-896.1980"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.2017-2020.2002"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.3.505"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1589-1597.2003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01603"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00127"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00178"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200802000-00007"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.595-597.2006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.080"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42435-z"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.117"},{"key":"e_1_2_8_47_1","first-page":"208","article-title":"In vitro activity of recombinant lysostaphin in combination with linezolid, vancomycin and oxacillin against methicillin\u2010resistant Staphylococcus aureus","volume":"9","author":"Narasimhaswamy N.","year":"2017","journal-title":"Iran J Microbiol"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(91)78612-8"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(03)00391-X"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200011000-00031"},{"key":"e_1_2_8_51_1","first-page":"208","article-title":"In vitro activity of recombinant lysostaphin\u2010antibiotic combinations toward methicillin\u2010resistant Staphylococcus aureus","volume":"9","author":"Polak J.","year":"1993","journal-title":"Diagn Microbiol Infect Dis"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/AM.22.3.446-450.1971"},{"key":"e_1_2_8_53_1","first-page":"86","article-title":"Methicillin\u2010resistant Staphylococcus aureus: a growing risk in the hospital and in the community","volume":"2","author":"Raygada J.L.","year":"2009","journal-title":"Am Heal Drug Benefits"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01056-18"},{"key":"e_1_2_8_55_1","first-page":"257","article-title":"The prevalence of nasal carriage of Staphylococcus aureus among healthcare workers at a tertiary care hospital in Assam with special reference to MRSA","volume":"7","author":"Rongpharpi S.R.","year":"2013","journal-title":"J Clin Diagnostic Res"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12929"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2704-2707.2004"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-020-00714-9"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1086\/527392"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1086\/430352"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197408012910507"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3071988"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.07.017"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2013.02.005"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2018.11.002"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12568"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.4.523"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.2911657.x"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-018-9730-4"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1078"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.554-558.2003"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm991"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.10.3586-3590.2001"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70295-4"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115940"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3407-3414.2003"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113797"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13066"},{"key":"e_1_2_8_80_1","article-title":"Systematic review and meta\u2010analysis of the epidemiology of vancomycin\u2010intermediate and heterogeneous vancomycin\u2010intermediate Staphylococcus aureus isolates","volume":"10","author":"Zhang S.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb9011"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jam.14985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jam.14985","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jam.14985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T09:34:28Z","timestamp":1676367268000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/131\/3\/1072\/6715268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jam.14985"],"URL":"https:\/\/doi.org\/10.1111\/jam.14985","archive":["Portico"],"relation":{},"ISSN":["1364-5072","1365-2672"],"issn-type":[{"value":"1364-5072","type":"print"},{"value":"1365-2672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]}}}