{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:45:17Z","timestamp":1785609917979,"version":"3.56.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFD0501403"],"award-info":[{"award-number":["2018YFD0501403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFD0500600"],"award-info":[{"award-number":["2018YFD0500600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study was conducted to investigate the effects of dietary tributyrin (TB) and physterol ester (PSE) supplementation on the growth performance and intestinal health of weaned piglets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Ninety-six piglets were randomly allocated to one of four groups, including a control group (basal diet), TB group (basal diet + 1500 g t\u22121 TB), PSE group (basal diet + 300 g t\u22121 PSE) and TB + PSE group (basal diet + 1500 g t\u22121 TB + 300 g t\u22121 PSE). All groups had eight replicates with three piglets per replicate. The experiment lasted for 28 days. The results showed that dietary TB supplementation increased (p &amp;lt; 0.05) average daily feed intake and average daily gain, as well as the acetate and butyrate concentration in ileum, and dietary PSE supplementation decreased (p &amp;lt; 0.05) the ratio of feed to gain (F\/G) on days 1\u201314 of the trial. Dietary TB or PSE alone supplementation improved the ratio of villus height to crypt depth (VH\/CD) and the expression level of Occludin in ileum. The linear discriminant analysis effect size analysis identified eight biomarkers in the control group, 18 in the TB + PSE group, two in the PSE group in ileum respectively. Correlation analysis showed that the relative abundances of Enterococcus, and Streptococcus were positively correlated (p &amp;lt; 0.05) with propionate concentration, while the relative abundance of Clostridium_sensu_stricto_1 was negatively correlated (p &amp;lt; 0.05) with acetate concentration in ileum.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings suggest that dietary TB or PSE alone supplementation could alter the growth performance, intestinal morphology, microbiota community and metabolites of weaned piglets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Significance and Impact of the Study<\/jats:title>\n                  <jats:p>Weaning stress is a major cause of slow growth and increased diarrhoea in piglets. This study demonstrated that dietary TB and PSE presented a beneficial role in growth performance and gut health via regulating intestinal morphology, microbiota composition and metabolites.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jam.15321","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T18:28:04Z","timestamp":1635359284000},"page":"2293-2305","source":"Crossref","is-referenced-by-count":16,"title":["Effects of dietary tributyrin and physterol ester supplementation on growth performance, intestinal morphology, microbiota and metabolites in weaned piglets"],"prefix":"10.1093","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5693-2702","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Hunan Co-Innovation of Animal Production Safety Changsha Hunan 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Technology Hunan Agricultural University Hunan Co-Innovation of Animal Production Safety Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Hunan Co-Innovation of Animal Production Safety Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Hunan Co-Innovation of Animal Production Safety Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Hunan Co-Innovation of Animal Production Safety Changsha Hunan China"},{"name":"Key Laboratory of Agroecology and Processing 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