{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:57:05Z","timestamp":1784159825843,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":261,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fujian Natural Science Foundation","award":["2020J05258"],"award-info":[{"award-number":["2020J05258"]}]},{"DOI":"10.13039\/501100017543","name":"Fujian Provincial Hospital","doi-asserted-by":"publisher","award":["(2017)510#"],"award-info":[{"award-number":["(2017)510#"]}],"id":[{"id":"10.13039\/501100017543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Science and Technology Program of Fujian Province","award":["2020GGA006"],"award-info":[{"award-number":["2020GGA006"]}]},{"DOI":"10.13039\/501100017543","name":"Fujian Provincial Hospital","doi-asserted-by":"publisher","award":["2020HSJJ09"],"award-info":[{"award-number":["2020HSJJ09"]}],"id":[{"id":"10.13039\/501100017543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate the clinical and genetic virulence characteristics of critically ill patients with hypervirulent Klebsiella pneumoniae (hvKP) and classic KP (cKP) infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>The patients included in this retrospective study (n = 225) were grouped according to their hvKP (n = 114) or cKP (n = 111) status, and their clinical characteristics were analysed and compared. Cox multivariate analysis was conducted to determine the risk factors for hvKP infection. Length of hospital stay, length of intensive care unit stay, duration of mechanical ventilation and 28-day survival rate were similar between the groups. However, the incidence of septic shock was higher in the hvKP group (16.7%) than in the cKP group (8.1%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There was a high rate of hvKP infection in this population. Compared to patients with cKP infection, those with hvKP infection showed a higher probability of having septic shock; nevertheless, survival and length of hospital stay were similar between the groups. Risk factors for hvKP infection included hospital-acquired infection and renal insufficiency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Significance and Impact of the Study<\/jats:title>\n                  <jats:p>This study presents relevant information on the characteristics of hvKP infection in a Chinese population, and this promotes early diagnosis and supports the view that the prevalence of hvKP is high in China.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jam.15476","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T11:10:35Z","timestamp":1644232235000},"page":"3883-3890","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of hypervirulent <i>Klebsiella pneumoniae<\/i> and classic <i>Klebsiella pneumoniae<\/i> infections in a Chinese hospital"],"prefix":"10.1093","volume":"132","author":[{"given":"Dongjie","family":"Chen","sequence":"first","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Clinical Microbiology Laboratory Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Department of Surgical Critical Care Medicine Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafang","family":"Wu","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Department of Surgical Critical Care Medicine Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Department of Surgical Critical Care Medicine Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Department of Surgical Critical Care Medicine Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Department of Surgical Critical Care Medicine Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlan","family":"Hu","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Clinical Microbiology Laboratory Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falin","family":"Chen","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Clinical Microbiology Laboratory Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-050X","authenticated-orcid":false,"given":"Rongguo","family":"Yu","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University Fuzhou China"},{"name":"Department of Surgical Critical Care Medicine Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"key":"2023011711212241100_jam15476-bib-0001","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1128\/JCM.01924-13","article-title":"wzi Gene sequencing, a rapid method for determination of capsular type for Klebsiella strains","volume":"51","author":"Brisse","year":"2013","journal-title":"Journal of Clinical Microbiology"},{"key":"2023011711212241100_jam15476-bib-0002","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1080\/21505594.2017.1317412","article-title":"Hypervirulence and hypermucoviscosity: Two different but complementary Klebsiella spp. phenotypes?","volume":"8","author":"Catal\u00e1n-N\u00e1jera","year":"2017","journal-title":"Virulence"},{"key":"2023011711212241100_jam15476-bib-0003","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fcimb.2017.00515","article-title":"Klebsiella pneumoniae in Singapore: hypervirulent infections and the carbapenemase threat","volume":"7","author":"Chew","year":"2017","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"2023011711212241100_jam15476-bib-0004","doi-asserted-by":"crossref","first-page":"fnw219","DOI":"10.1093\/femsle\/fnw219","article-title":"The emerging problems of Klebsiella pneumoniae infections: carbapenem resistance and biofilm formation","volume":"363","author":"Chung","year":"2016","journal-title":"FEMS Microbiology Letters"},{"key":"2023011711212241100_jam15476-bib-0005","volume-title":"Performance standards for antimicrobial susceptibility testing 27th ed CLSI supplement M100-S27","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2017"},{"key":"2023011711212241100_jam15476-bib-0006","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cmi.2015.09.025","article-title":"Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007\u20132013)","volume":"22","author":"Cubero","year":"2016","journal-title":"Clinical Microbiology and Infection"},{"key":"2023011711212241100_jam15476-bib-0007","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/JCM.00676-11","article-title":"Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France","volume":"49","author":"Decr\u00e9","year":"2011","journal-title":"Journal of Clinical Microbiology"},{"key":"2023011711212241100_jam15476-bib-0008","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20030857","article-title":"A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications","volume":"199","author":"Fang","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"key":"2023011711212241100_jam15476-bib-0009","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1086\/519262","article-title":"Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess","volume":"45","author":"Fang","year":"2007","journal-title":"Clinical Infectious Diseases"},{"key":"2023011711212241100_jam15476-bib-0010","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3201\/eid1808.111053","article-title":"Klebsiella pneumoniae in gastrointestinal tract and pyogenic liver abscess","volume":"18","author":"Fung","year":"2012","journal-title":"Emerging Infectious Diseases"},{"key":"2023011711212241100_jam15476-bib-0011","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fcimb.2017.00024","article-title":"Microbiological and clinical characteristics of hypermucoviscous Klebsiella pneumoniae isolates associated with invasive infections in China","volume":"7","author":"Guo","year":"2017","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"2023011711212241100_jam15476-bib-0012","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1080\/21505594.2016.1186315","article-title":"Impact of glycemic control on capsular polysaccharide biosynthesis and opsonophagocytosis of Klebsiella pneumoniae: Implications for invasive syndrome in patients with diabetes mellitus","volume":"7","author":"Lee","year":"2016","journal-title":"Virulence"},{"key":"2023011711212241100_jam15476-bib-0013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/cid\/cit675","article-title":"Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China","volume":"58","author":"Li","year":"2014","journal-title":"Clinical Infectious Diseases"},{"key":"2023011711212241100_jam15476-bib-0014","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13756-018-0371-8","article-title":"Characteristics of ventilator-associated pneumonia due to hypervirulent Klebsiella pneumoniae genotype in genetic background for the elderly in two tertiary hospitals in China","volume":"7","author":"Liu","year":"2018","journal-title":"Antimicrobial Resistance and Infection Control"},{"key":"2023011711212241100_jam15476-bib-0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12941-018-0302-9","article-title":"Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor","volume":"18","author":"Liu","year":"2019","journal-title":"Annals of Clinical Microbiology and Antimicrobials"},{"key":"2023011711212241100_jam15476-bib-0016","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1001\/archinte.1986.00360220057011","article-title":"Klebsiella pneumoniae liver abscess associated with septic endophthalmitis","volume":"146","author":"Liu","year":"1986","journal-title":"Archives of Internal Medicine"},{"key":"2023011711212241100_jam15476-bib-0017","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcimb.2018.00004","article-title":"Colonization, infection, and the accessory genome of Klebsiella pneumonia","volume":"8","author":"Martin","year":"2017","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"2023011711212241100_jam15476-bib-0018","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1099\/jmm.0.000788","article-title":"Hypervirulent Klebsiella pneumoniae, a 5-year study in a French ICU","volume":"67","author":"Rafat","year":"2018","journal-title":"Journal of Medical Microbiology"},{"key":"2023011711212241100_jam15476-bib-0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2019.e00547","article-title":"Hypermucoviscous Klebsiella pneumoniae: a challenge in community acquired infection","volume":"17","author":"S\u00e1nchez-L\u00f3pez","year":"2019","journal-title":"IDCases"},{"key":"2023011711212241100_jam15476-bib-0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4161\/viru.22718","article-title":"Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed","volume":"4","author":"Shon","year":"2013","journal-title":"Virulence"},{"key":"2023011711212241100_jam15476-bib-0021","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1473-3099(12)70205-0","article-title":"Klebsiella pneumoniae liver abscess: a new invasive syndrome","volume":"12","author":"Siu","year":"2012","journal-title":"The Lancet Infectious Diseases"},{"key":"2023011711212241100_jam15476-bib-0022","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1128\/IAI.01523-08","article-title":"Genetic requirements for Klebsiella pneumoniae-induced liver abscess in an oral infection model","volume":"77","author":"Tu","year":"2009","journal-title":"Infection and Immunity"},{"key":"2023011711212241100_jam15476-bib-0023","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/1874285801105010107","article-title":"Appearance of Klebsiella pneumoniae liver abscess syndrome in Argentina: case report and review of molecular mechanisms of pathogenesis","volume":"5","author":"Vila","year":"2011","journal-title":"Open Microbiol J"},{"key":"2023011711212241100_jam15476-bib-0024","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1086\/516369","article-title":"Primary liver abscess due to Klebsiella pneumoniae in Taiwan","volume":"26","author":"Wang","year":"1998","journal-title":"Clinical Infectious Diseases"},{"key":"2023011711212241100_jam15476-bib-0025","first-page":"176","article-title":"Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae","volume":"37","author":"Yang","year":"2004","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"2023011711212241100_jam15476-bib-0026","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fmicb.2015.00721","article-title":"First report of two rapid-onset fatal infections caused by a newly emerging hypervirulent K. Pneumonia ST86 strain of serotype K2 in China","volume":"6","author":"Zhang","year":"2015","journal-title":"Frontiers in Microbiology"},{"key":"2023011711212241100_jam15476-bib-0027","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1128\/AAC.01127-16","article-title":"High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance","volume":"60","author":"Zhang","year":"2016","journal-title":"Antimicrobial Agents and Chemotherapy"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jam.15476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jam.15476","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/132\/5\/3883\/48730496\/jambio3883.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/132\/5\/3883\/48730496\/jambio3883.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T14:52:57Z","timestamp":1673967177000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/132\/5\/3883\/6988749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,1]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,1]]},"published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jam.15476","relation":{},"ISSN":["1365-2672","1364-5072"],"issn-type":[{"value":"1365-2672","type":"electronic"},{"value":"1364-5072","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2022,5,1]]}}}