{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:24:40Z","timestamp":1792293880390,"version":"4.4.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV-17-0028"],"award-info":[{"award-number":["APVV-17-0028"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["VEGA 2\/0056\/19"],"award-info":[{"award-number":["VEGA 2\/0056\/19"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To study the local intestinal lymphocyte immunity in mice with trichinellosis affected by probiotic bacteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Enterococcus faecium CCM8558, Enterococcus durans ED26E\/7, Limosilactobacillus fermentum CCM7421 and Lactiplantibacillus plantarum 17 L\/1 were administered daily (109 CFU ml\u22121) and mice were infected with Trichinella spiralis (400 larvae) on the 7th day of treatment. T. spiralis infection significantly inhibited lymphocyte subpopulations from 5 to 25 days postinfection (dpi). L. fermentum CCM7421 and L. plantarum 17 L\/1 restored the CD4+ T cell numbers in the epithelium and lamina propria at the control level from 11 dpi. All strains stimulated the CD8+ T cells numbers in infected mice, which were restored in the lamina propria on 11 dpi and in the epithelium only on 32 dpi. B cells (CD19+) inhibition after T. spiralis infection was not affected by treatment till 25 dpi.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The strain-specific immunomodulatory effect of tested bacteria was confirmed. L. fermentum CCM7421 and L. plantarum 17 L\/1 showed the greatest immunomodulatory potential on CD4+ and CD8+ T lymphocytes in trichinellosis. E. faecium CCM8558 and E. durans ED26E\/7 activated only CD8+ T cells in the lamina propria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Significance and Impact of the Study<\/jats:title>\n                  <jats:p>Positive modulation of the gut lymphocyte immunity in T. spiralis infection with bacterial strains showed their beneficial effect with the host\u2032s antiparasitic defence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jam.15534","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T11:43:22Z","timestamp":1647690202000},"page":"4430-4439","source":"Crossref","is-referenced-by-count":5,"title":["Modulation of lymphocyte subpopulations in the small intestine of mice treated with probiotic bacterial strains and infected with <i>Trichinella spiralis<\/i>"],"prefix":"10.1093","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-6125","authenticated-orcid":false,"given":"Em\u00edlia","family":"Dvoro\u017e\u0148\u00e1kov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Parasitology Slovak Academy of Sciences Ko\u0161ice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Vargov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Parasitology Slovak Academy of Sciences Ko\u0161ice Slovak Republic"},{"name":"University of Veterinary Medicine and Pharmacy in Ko\u0161ice Ko\u0161ice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Hurn\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Parasitology Slovak Academy of Sciences Ko\u0161ice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Laukov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology Centre of Biosciences of the Slovak Academy of Sciences Ko\u0161ice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viera","family":"Revajov\u00e1","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine and Pharmacy in Ko\u0161ice Ko\u0161ice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2023011712025492000_jam15534-bib-0001","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fcimb.2012.00141","article-title":"Interactions between parasites and microbial communities in the human gut","volume":"2","author":"Berrilli","year":"2012","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"3","key":"2023011712025492000_jam15534-bib-0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0147-9571(98)00014-9","article-title":"Gamma deltaTCR+ intestinal intraepithelial lymphocytes (i-IEL) in reaction against intestinal nematode Trichinella spiralis","volume":"21","author":"Bo\u017ei\u0107","year":"1998","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"issue":"1","key":"2023011712025492000_jam15534-bib-0003","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14411\/fp.2000.010","article-title":"Analysis of intestinal intraepithelial lymphocyte populations in experimental Trichinella spiralis infection of mice","volume":"47","author":"Bo\u017ei\u0107","year":"2000","journal-title":"Folia Parasitologica"},{"key":"2023011712025492000_jam15534-bib-0004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-0346-0136-8_2","volume-title":"Principles of immunopharmacology","author":"Broere","year":"2011"},{"issue":"4","key":"2023011712025492000_jam15534-bib-0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000024206","article-title":"Anaphylactic response to parasite antigens: IgE and IgG1 independently induce death in Trichinella-infected mice","volume":"119","author":"Bruschi","year":"1999","journal-title":"International Archives of Allergy and Immunology"},{"issue":"3","key":"2023011712025492000_jam15534-bib-0006","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3855\/jidc.2478","article-title":"Trichinellosis in developing countries: is it neglected?","volume":"6","author":"Bruschi","year":"2012","journal-title":"Journal of Infection in Developing Countries"},{"issue":"1","key":"2023011712025492000_jam15534-bib-0007","first-page":"18","article-title":"Effect of probiotic strains on the T-cell subsets and cytokine production in mice","volume":"59","author":"Buckov\u00e1","year":"2015","journal-title":"Folia Veterinaria"},{"issue":"2","key":"2023011712025492000_jam15534-bib-0008","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2478\/helm-2018-0010","article-title":"The anti-parasitic effect of probiotic bacteria via limiting the fecundity of Trichinella spiralis female adults","volume":"55","author":"Buckov\u00e1","year":"2018","journal-title":"Helminthologia"},{"issue":"1\u20132","key":"2023011712025492000_jam15534-bib-0009","first-page":"37","article-title":"Immunomodulatory effects of probiotics in the intestinal tract","volume":"10","author":"Delcenserie","year":"2008","journal-title":"Current Issues in Molecular Biology"},{"issue":"2","key":"2023011712025492000_jam15534-bib-0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imbio.2007.07.002","article-title":"Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages","volume":"213","author":"de Moreno de LeBlanc","year":"2008","journal-title":"Immunobiology"},{"issue":"11","key":"2023011712025492000_jam15534-bib-0011","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s00284-017-1318-7","article-title":"Probiotics and probiotic metabolic product improved intestinal function and ameliorated LPS-induced injury in rats","volume":"74","author":"Deng","year":"2017","journal-title":"Current Microbiology"},{"issue":"8","key":"2023011712025492000_jam15534-bib-0012","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0169-4758(98)01287-3","article-title":"How does Trichinella spiralis make itself at home?","volume":"14","author":"Despommier","year":"1998","journal-title":"Parasitology Today"},{"key":"2023011712025492000_jam15534-bib-0013","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vetpar.2016.07.019","article-title":"Developmental profile of select immune cells in mice infected with Trichinella spiralis during the intestinal phase","volume":"231","author":"Ding","year":"2016","journal-title":"Veterinary Parasitology"},{"issue":"7","key":"2023011712025492000_jam15534-bib-0014","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/1469-0691.12162","article-title":"Pork as a source of human parasitic infection","volume":"19","author":"Djurkovi\u0107-Djakovi\u0107","year":"2013","journal-title":"Clinical Microbiology and Infection"},{"key":"2023011712025492000_jam15534-bib-0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.vetpar.2016.07.004","article-title":"Effect of probiotic bacteria on phagocytosis and respiratory burst activity of blood polymorphonuclear leukocytes (PMNL) in mice infected with Trichinella spiralis","volume":"231","author":"Dvoro\u017e\u0148\u00e1kov\u00e1","year":"2016","journal-title":"Veterinary Parasitology"},{"issue":"1","key":"2023011712025492000_jam15534-bib-0016","doi-asserted-by":"crossref","first-page":"33","DOI":"10.18388\/abp.2006_3361","article-title":"Molecules released by helminth parasites involved in host colonization","volume":"53","author":"Dzik","year":"2006","journal-title":"Acta Biochimica Polonica"},{"issue":"1","key":"2023011712025492000_jam15534-bib-0017","first-page":"22","article-title":"Probiotics: an update on mechanisms of action and clinical applications","volume":"2","author":"Goudarzi","year":"2014","journal-title":"Novelty in Biomedicine"},{"issue":"5","key":"2023011712025492000_jam15534-bib-0018","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s10620-012-2503-y","article-title":"Probiotic lactobacillus rhamnosus GG modulates the mucosal immune response in Giardia intestinalis-infected BALB\/c mice","volume":"58","author":"Goyal","year":"2013","journal-title":"Digestive Diseases and Sciences"},{"issue":"1","key":"2023011712025492000_jam15534-bib-0019","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1515\/helm-2017-0002","article-title":"Molecular identification of Trichinella isolates from wildlife animals of the Russian Arctic territories","volume":"54","author":"Go\u017adzik","year":"2017","journal-title":"Helminthologia"},{"issue":"3","key":"2023011712025492000_jam15534-bib-0020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4103\/0255-0857.53201","article-title":"Probiotics","volume":"27","author":"Gupta","year":"2009","journal-title":"Indian Journal of Medical Microbiology"},{"key":"2023011712025492000_jam15534-bib-0021","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3389\/fmicb.2015.01285","article-title":"Molecular players involved in the interaction between beneficial bacteria and the immune system","volume":"6","author":"Hevia","year":"2015","journal-title":"Frontiers in Microbiology"},{"issue":"2","key":"2023011712025492000_jam15534-bib-0022","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/mi.2007.16","article-title":"Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection","volume":"1","author":"Ierna","year":"2008","journal-title":"Mucosal Immunology"},{"issue":"2","key":"2023011712025492000_jam15534-bib-0023","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1053\/gast.1997.v113.pm9247474","article-title":"Role of T helper 2 cells in intestinal goblet cell hyperplasia in mice infected with Trichinella spiralis","volume":"113","author":"Ishikawa","year":"1997","journal-title":"Gastroenterology"},{"issue":"6","key":"2023011712025492000_jam15534-bib-0024","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1017\/S0031182008004381","article-title":"Physiological changes in the gastrointestinal tract and host protective immunity: learning from the mouse-Trichinella spiralis model","volume":"135","author":"Khan","year":"2008","journal-title":"Parasitology"},{"issue":"3\u20134","key":"2023011712025492000_jam15534-bib-0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0304-4017(00)00352-6","article-title":"Trichinellosis: human disease, diagnosis and treatment","volume":"93","author":"Koci\u0119cka","year":"2000","journal-title":"Veterinary Parasitology"},{"issue":"8","key":"2023011712025492000_jam15534-bib-0026","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1023\/B:VERC.0000045948.04027.a7","article-title":"Adhesion properties of enterococci to intestinal mucus of different hosts","volume":"28","author":"Laukov\u00e1","year":"2004","journal-title":"Veterinary Research Communications"},{"issue":"4","key":"2023011712025492000_jam15534-bib-0027","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12602-012-9118-7","article-title":"Enterococcus faecium AL41: its enterocin M and their beneficial use in rabbits husbandry","volume":"4","author":"Laukov\u00e1","year":"2012","journal-title":"Probiotics and Antimicrobial Proteins"},{"issue":"Suppl. 1","key":"2023011712025492000_jam15534-bib-0028","first-page":"21","article-title":"Bacteriocin-like activity of strain lactobacillus plantarum 17L\/1 isolated from stored sheep cheese","volume":"57","author":"Laukov\u00e1","year":"2013","journal-title":"Folia Veterinaria"},{"issue":"4","key":"2023011712025492000_jam15534-bib-0029","doi-asserted-by":"crossref","first-page":"168","DOI":"10.17221\/21\/2016-CJAS","article-title":"Beneficial effect of bacteriocin-producing strain enterococcus durans ED 26E\/7 in model experiment using broiler rabbits","volume":"62","author":"Laukov\u00e1","year":"2017","journal-title":"Czech Journal of Animal Science"},{"issue":"3","key":"2023011712025492000_jam15534-bib-0030","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2527\/jas.2008-0919","article-title":"Administration of Pediococcus acidilactici or Saccharomyces cerevisiae boulardii modulates development of porcine mucosal immunity and reduces intestinal bacterial translocation after Escherichia coli challenge","volume":"87","author":"Lessard","year":"2009","journal-title":"Journal of Animal Science"},{"issue":"8","key":"2023011712025492000_jam15534-bib-0031","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10295-007-0226-4","article-title":"Isolation and characterization of a new bacteriocin, termed enterocin M, produced by environmental isolate enterococcus faecium AL41","volume":"34","author":"Marekov\u00e1","year":"2007","journal-title":"Journal of Industrial Microbiology & Biotechnology"},{"issue":"1","key":"2023011712025492000_jam15534-bib-0032","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/IAI.70.1.233-239.2002","article-title":"Increased CD8+-T-cell expression and a type 2 cytokine pattern during the muscular phase of Trichinella infection in humans","volume":"70","author":"Morales","year":"2002","journal-title":"Infection and Immunity"},{"issue":"4","key":"2023011712025492000_jam15534-bib-0033","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1057","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens","volume":"3","author":"Mowat","year":"2003","journal-title":"Nature Reviews Immunology"},{"key":"2023011712025492000_jam15534-bib-0034","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbi.2013.08.015","article-title":"Influence of a probiotic lactobacillus strain on the intestinal ecosystem in a stress model mouse","volume":"35","author":"Palomar","year":"2014","journal-title":"Brain, Behavior, and Immunity"},{"issue":"1\u20132","key":"2023011712025492000_jam15534-bib-0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vetimm.2015.06.006","article-title":"Immunomodulatory activity and control of salmonella enteritidis colonization in the intestinal tract of chickens by Lactobacillus based probiotic","volume":"167","author":"Penha Filho","year":"2015","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"2023011712025492000_jam15534-bib-0036","volume-title":"Quality and characterization of existing and new probiotic (EFSA QPS)","author":"Piskor\u00edkov\u00e1","year":"2010"},{"issue":"4","key":"2023011712025492000_jam15534-bib-0037","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4269\/ajtmh.1993.48.568","article-title":"Comparison of human trichinellosis caused by Trichinella spiralis and by Trichinella britovi","volume":"48","author":"Pozio","year":"1993","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"2023011712025492000_jam15534-bib-0038","article-title":"Isolating lymphocytes from the mouse small intestinal immune system","volume":"132","author":"Qiu","year":"2018","journal-title":"Journal of Visualized Experiments"},{"issue":"1\u20132","key":"2023011712025492000_jam15534-bib-0039","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-1759(00)00209-X","article-title":"Isolation and purification of lymphocyte subsets from gut-associated lymphoid tissue in neonatal swine","volume":"241","author":"Solano-Aguilar","year":"2000","journal-title":"Journal of Immunological Methods"},{"issue":"2","key":"2023011712025492000_jam15534-bib-0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.anaerobe.2005.12.001","article-title":"Applicastion of potential probiotic Lactobacillus fermentum AD1 strain in healthy dogs","volume":"12","author":"Strompfov\u00e1","year":"2006","journal-title":"Anaerobe"},{"key":"2023011712025492000_jam15534-bib-0041","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/610769","article-title":"Probiotics for the control of parasites: an overview","volume":"2011","author":"Travers","year":"2011","journal-title":"Journal of Parasitology Research"},{"issue":"11","key":"2023011712025492000_jam15534-bib-0042","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.1128\/IAI.67.11.6090-6097.1999","article-title":"CD4 T cells and major histocompatibility complex class II expression influence worm expulsion and increased intestinal muscle contraction during Trichinella spiralis infection","volume":"67","author":"Vallance","year":"1999","journal-title":"Infection and Immunity"},{"issue":"3","key":"2023011712025492000_jam15534-bib-0043","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2478\/helm-2020-0024","article-title":"Probiotic bacteria can modulate murine macrophage\u2032s superoxide production in Trichinella spiralis infection","volume":"57","author":"Vargov\u00e1","year":"2020","journal-title":"Helminthologia"},{"issue":"4","key":"2023011712025492000_jam15534-bib-0044","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2307\/3283372","article-title":"Trichinella spiralis: immunity, ecology, and evolution","volume":"79","author":"Wakelin","year":"1993","journal-title":"Journal of Parasitology"},{"issue":"3","key":"2023011712025492000_jam15534-bib-0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1365-3024.1988.tb00222.x","article-title":"Antibody-mediated in-vivo cytotoxicity to Trichinella spiralis newborn larvae in immune rats","volume":"10","author":"Wang","year":"1988","journal-title":"Parasite Immunology"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jam.15534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jam.15534","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/132\/6\/4430\/48730840\/jambio4430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/132\/6\/4430\/48730840\/jambio4430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T16:29:45Z","timestamp":1673972985000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/132\/6\/4430\/6988792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,1]]},"published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jam.15534","relation":{},"ISSN":["1365-2672","1364-5072"],"issn-type":[{"value":"1365-2672","type":"electronic"},{"value":"1364-5072","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,6,1]]}}}