{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:58:43Z","timestamp":1791395923008,"version":"4.3.3"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BIOMIN GmbH"},{"DOI":"10.13039\/100010132","name":"National Foundation for Research, Technology and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012416","name":"Federal Ministry for Digital and Economic Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to characterize the critical points for determining the development of dysbiosis associated with feed intolerances and ruminal acidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>A metabologenomics approach was used to characterize dynamic microbial and metabolomics shifts using the rumen simulation technique (RUSITEC) by feeding native cornstarch (ST), chemically modified cornstarch (CMS), or sucrose (SU). SU and CMS elicited the most drastic changes as rapidly as 4 h after feeding. This was accompanied by a swift accumulation of d-lactate, and the decline of benzoic and malonic acid. A consistent increase in Bifidobacterium and Lactobacillus as well as a decrease in fibrolytic bacteria was observed for both CMS and ST after 24 h, indicating intolerances within the fibre degrading populations. However, an increase in Lactobacillus was already evident in SU after 8 h. An inverse relationship between Fibrobacter and Bifidobacterium was observed in ST. In fact, Fibrobacter was positively correlated with several short-chain fatty acids, while Lactobacillus was positively correlated with lactic acid, hexoses, hexose-phosphates, pentose phosphate pathway (PENTOSE-P-PWY), and heterolactic fermentation (P122-PWY).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The feeding of sucrose and modified starches, followed by native cornstarch, had a strong disruptive effect in the ruminal microbial community. Feed intolerances were shown to develop at different rates based on the availability of glucose for ruminal microorganisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance and Impact of the study<\/jats:title>\n                    <jats:p>These results can be used to establish patterns of early dysbiosis (biomarkers) and develop strategies for preventing undesirable shifts in the ruminal microbial ecosystem.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jam.15573","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T04:34:04Z","timestamp":1649478844000},"page":"458-476","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of microbial intolerances and ruminal dysbiosis towards different dietary carbohydrate sources using an in vitro model"],"prefix":"10.1093","volume":"133","author":[{"given":"Parisa","family":"Kheirandish","sequence":"first","affiliation":[{"name":"Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Department for Farm Animals and Veterinary Public Health Institute of Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee Maxine","family":"Petri","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Sherbrooke Research and Development Centre Sherbrooke Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arife","family":"Sener-Aydemir","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Department for Farm Animals and Veterinary Public Health Institute of Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Elisabeth","family":"Schwartz-Zimmermann","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Department of Agrobiotechnology (IFA-Tulln) Institute of Bioanalytics and Agro-Metabolomics, University of Natural Resources and Life Sciences Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Berthiller","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Department of Agrobiotechnology (IFA-Tulln) Institute of Bioanalytics and Agro-Metabolomics, University of Natural Resources and Life Sciences Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qendrim","family":"Zebeli","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Innovative Gut Health Concepts of 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