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One of these interventions is to disrupt the pseudomonas quinolone signal (pqs) quorum sensing (QS) system, which governs multiple virulence traits and biofilm formation. This study aimed to investigate the QS inhibitory activity of a series of new PqsR inhibitors bearing a quinoline scaffold against Ps. aeruginosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>The results showed that compound 1 suppressed the expression of QS-related genes and showed the best inhibitory activity to the pqs system of wild-type Ps. aeruginosa PAO1 with an IC50 of 20.22 \u03bcmol L\u22121. The virulence factors including pyocyanin, total protease, elastase and rhamnolipid were significantly suppressed in a concentration-dependent manner with the compound. In addition, compound 1 in combination with tetracycline inhibited synergistically the bacterial growth and suppressed the biofilm formation of PAO1. The molecular docking studies also suggested that compound 1 could potentially interact with the ligand-binding domain of the Lys-R type transcriptional regulator PqsR as a competitive antagonist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The quinoline-based derivatives were found to interrupt the quorum sensing system via the pqs pathway and thus the production of virulence factors was inhibited and the antimicrobial susceptibility of Ps. aeruginosa was enhanced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance and Impact of Study<\/jats:title>\n                    <jats:p>The study showed that the quinoline-based derivatives could be used as an anti-virulence agent for treating Ps. aeruginosa infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jam.15601","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T01:09:35Z","timestamp":1651367375000},"page":"2167-2181","source":"Crossref","is-referenced-by-count":26,"title":["Novel quinoline-based derivatives as the PqsR inhibitor against Pseudomonas aeruginosa PAO1"],"prefix":"10.1093","volume":"133","author":[{"given":"Xuan-He","family":"Huang","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ting","family":"She","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Xiao","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou P. R. 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