{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:03:21Z","timestamp":1793657001925,"version":"4.5.1"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Province Qiu Shengxiang Expert Workstation","award":["202005AF150039"],"award-info":[{"award-number":["202005AF150039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intestinal microbiota is considered to play an integral role in maintaining health of host by modulating several physiological functions including nutrition, metabolism and immunity. Accumulated data from human and animal studies indicate that intestinal microbes can affect lipid metabolism in host through various direct and indirect biological mechanisms. These mechanisms include the production of various signalling molecules by the intestinal microbiome, which exert a strong effect on lipid metabolism, bile secretion in the liver, reverse transport of cholesterol and energy expenditure and insulin sensitivity in peripheral tissues. This review discusses the findings of recent studies suggesting an emerging role of intestinal microbiota and its metabolites in regulating lipid metabolism and the association of intestinal microbiota with obesity. Additionally, we discuss the controversies and challenges in this research area. However, intestinal micro-organisms are also affected by some external factors, which in turn influence the regulation of microbial lipid metabolism. Therefore, we also discuss the effects of probiotics, prebiotics, diet structure, exercise and other factors on intestinal microbiological changes and lipid metabolism regulation.<\/jats:p>","DOI":"10.1111\/jam.15740","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T21:18:10Z","timestamp":1658870290000},"page":"2915-2930","source":"Crossref","is-referenced-by-count":47,"title":["The intestinal microbiome associated with lipid metabolism and obesity in humans and animals"],"prefix":"10.1093","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-4757","authenticated-orcid":false,"given":"Zonghui","family":"Jian","sequence":"first","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Chenggong Department Kunming Medical University Affiliated Stomatological Hospital Kunming People's Republic of China"},{"name":"Yunnan Key Laboratory of Stomatology Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taojie","family":"Xu","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiong","family":"Yan","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Genomics, College of Computing and Informatics The University of North Carolina at Charlotte Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changrong","family":"Ge","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, The First People's Hospital of Yunnan Province The Affiliated Hospital of Kunming University of Science and Technology Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjing","family":"Jia","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Dou","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"issue":"4","key":"2023011711241171600_jam15740-bib-0001","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2362.2011.02590.x","article-title":"Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects","volume":"42","author":"Al-Lahham","year":"2012","journal-title":"European Journal of Clinical Investigation"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0002","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2362.2010.02278.x","article-title":"Regulation of adipokine production in human adipose tissue by propionic acid","volume":"40","author":"Al-Lahham","year":"2010","journal-title":"European Journal of Clinical Investigation"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0003","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cgh.2019.07.006","article-title":"Effects of fecal microbiota transplantation with oral capsules in obese patients","volume":"18","author":"Allegretti","year":"2020","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"10","key":"2023011711241171600_jam15740-bib-0004","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1017\/S0007114520000380","article-title":"Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism","volume":"123","author":"Amabebe","year":"2020","journal-title":"The British Journal of Nutrition"},{"issue":"11","key":"2023011711241171600_jam15740-bib-0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109691","article-title":"Metabolic endotoxemia is dictated by the type of lipopolysaccharide","volume":"36","author":"Anh\u00ea","year":"2021","journal-title":"Cell Reports"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0006","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.chom.2021.12.008","article-title":"Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota","volume":"30","author":"Aranda-D\u00edaz","year":"2022","journal-title":"Cell Host & Microbe"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0007","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.chom.2020.01.028","article-title":"Fermentation products of commensal bacteria alter enterocyte lipid metabolism","volume":"27","author":"Ara\u00fajo","year":"2020","journal-title":"Cell Host & Microbe"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0008","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41591-020-0801-z","article-title":"Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans","volume":"26","author":"Basolo","year":"2020","journal-title":"Nature Medicine"},{"key":"2023011711241171600_jam15740-bib-0009","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00018-015-2083-z","article-title":"Regulation of energy balance by a gutebrain axis and involvement of the gut microbiota","volume":"73","author":"Bauer","year":"2016","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1897208","article-title":"Running after ghosts: are dead bacteria the dark matter of the human gut microbiota?","volume":"13","author":"Bellali","year":"2021","journal-title":"Gut Microbes"},{"issue":"9","key":"2023011711241171600_jam15740-bib-0011","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gutmicrobiota, and host energy metabolism","volume":"54","author":"Besten","year":"2013","journal-title":"Journal of Lipid Research"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0012","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nrgastro.2015.47","article-title":"Towards a more comprehensive concept for prebiotics","volume":"12","author":"Bindels","year":"2015","journal-title":"Natural Reviews. Gastroenterolog\u00eda y Hepatolog\u00eda"},{"key":"2023011711241171600_jam15740-bib-0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171352","article-title":"Differences in gut microbiota profile between women with active lifestyle and sedentary women","volume":"12","author":"Bressa","year":"2017","journal-title":"PLoS ONE"},{"issue":"13","key":"2023011711241171600_jam15740-bib-0014","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150502","article-title":"The effect of diet and exercise on intestinal integrity and microbial diversity in mice","volume":"11","author":"Campbell","year":"2016","journal-title":"PLoS ONE"},{"issue":"10","key":"2023011711241171600_jam15740-bib-0016","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","article-title":"Short-chain fatty acids in control of body weight and insulin sensitivity","volume":"11","author":"Canfora","year":"2015","journal-title":"Nature Reviews. Endocrinology"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0017","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut microbial metabolites in obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nature Reviews. Endocrinology"},{"issue":"7","key":"2023011711241171600_jam15740-bib-0018","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0019","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1051\/medsci\/20143002003","article-title":"Akkermansia muciniphila\u2014Une nouvelle cible pour contr\u00f4ler l'ob\u00e9sit\u00e9, le diab\u00e8te de type 2 et l'inflammation? [Akkermansia muciniphila: a novel target controlling obesity, type 2 diabetes and inflammation?]","volume":"30","author":"Cani","year":"2014","journal-title":"Medical Science (Paris)"},{"issue":"8","key":"2023011711241171600_jam15740-bib-0020","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0021","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/foods11030268","article-title":"Probiotics supplementation improves intestinal permeability, obesity index and metabolic biomarkers in elderly Thai subjects: a randomized controlled trial","volume":"11","author":"Chaiyasut","year":"2022","journal-title":"Food"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0022","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/nu12041082","article-title":"Gut microbiome, intestinal permeability, and tissue bacteria in metabolic disease: perpetrators or bystanders?","volume":"12","author":"Chakaroun","year":"2020","journal-title":"Nutrients"},{"issue":"11","key":"2023011711241171600_jam15740-bib-0023","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1136\/gutjnl-2014-307913","article-title":"Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults","volume":"64","author":"Chambers","year":"2015","journal-title":"Gut"},{"key":"2023011711241171600_jam15740-bib-0024","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.foodres.2018.07.013","article-title":"Role of prebiotics in regulation of microbiota and prevention of obesity","volume":"113","author":"Choque Delgado","year":"2018","journal-title":"Food Research International"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4161\/gmic.20168","article-title":"The gut microbiota and its relationship to diet and obesity","volume":"3","author":"Clarke","year":"2012","journal-title":"Gut Microbes"},{"issue":"12","key":"2023011711241171600_jam15740-bib-0026","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1136\/gutjnl-2013-306541","article-title":"Exercise and associated dietary extremes impact on gut microbial diversity","volume":"63","author":"Clarke","year":"2014","journal-title":"Gut"},{"key":"2023011711241171600_jam15740-bib-0027","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1096\/fj.201700697RR","article-title":"Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study","volume":"32","author":"Collado","year":"2018","journal-title":"The FASEB Journal"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0028","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11605-009-1045-x","article-title":"Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8","volume":"14","author":"Cresci","year":"2010","journal-title":"Journal of Gastrointestinal Surgery"},{"key":"2023011711241171600_jam15740-bib-0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2022.100168","article-title":"Gut mycobiome as a promising preventive and therapeutic target for metabolic disorders","volume":"13","author":"Dalamaga","year":"2022","journal-title":"Metabolism Open"},{"key":"2023011711241171600_jam15740-bib-0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/ATVBAHA.111.229997","article-title":"Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice","volume":"32","author":"Danzaki","year":"2012","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"2023011711241171600_jam15740-bib-0031","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0032","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/NT.0000000000000167","article-title":"The gut microbiome and its role in obesity","volume":"51","author":"Davis","year":"2016","journal-title":"Nutrition Today"},{"issue":"7","key":"2023011711241171600_jam15740-bib-0033","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-chain fatty acids protect against high-fat diet-induced obesity via a PPAR\u03b3-dependent switch from lipogenesis to fat oxidation","volume":"64","author":"Den Besten","year":"2015","journal-title":"Diabetes"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0034","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12711-016-0270-5","article-title":"Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota","volume":"48","author":"Ding","year":"2016","journal-title":"Genetics, Selection, Evolution"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nature Reviews. Microbiology"},{"issue":"10","key":"2023011711241171600_jam15740-bib-0036","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/pro.3484","article-title":"Bile salt hydrolases: structure and function, substrate preference and inhibitor development","volume":"27","author":"Dong","year":"2018","journal-title":"Protein Science"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12602-017-9329-z","article-title":"Gut microbiota and IL-17A: physiological and pathological responses","volume":"11","author":"Douzandeh-Mobarrez","year":"2019","journal-title":"Probiotics and Antimicrobial Proteins"},{"key":"2023011711241171600_jam15740-bib-0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humic.2018.08.002","article-title":"Early colonization of the gut microbiome and its relationship with obesity","volume":"10","author":"Dreyer","year":"2018","journal-title":"Human Microbiome Journal"},{"issue":"12","key":"2023011711241171600_jam15740-bib-0039","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3945\/jn.113.179549","article-title":"Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers","volume":"143","author":"Elamin","year":"2013","journal-title":"The Journal of Nutrition"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092193","article-title":"Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity","volume":"9","author":"Evans","year":"2014","journal-title":"PLoS ONE"},{"issue":"10","key":"2023011711241171600_jam15740-bib-0041","doi-asserted-by":"crossref","first-page":"G822","DOI":"10.1152\/ajpgi.00440.2015","article-title":"Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages","volume":"310","author":"Fernando","year":"2016","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"2023011711241171600_jam15740-bib-0042","first-page":"7588","article-title":"Probiotics, prebiotics and synbiotics for weight loss and metabolic syndrome in the microbiome era","volume":"22","author":"Ferrarese","year":"2018","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0043","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jbiosc.2014.03.001","article-title":"Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet","volume":"118","author":"Gao","year":"2014","journal-title":"Journal of Bioscience and Bioengineering"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0044","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1038\/s41598-020-61723-7","article-title":"Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system","volume":"10","author":"Geng","year":"2020","journal-title":"Scientific Reports"},{"issue":"12","key":"2023011711241171600_jam15740-bib-0045","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.2337\/dc09-0979","article-title":"Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance","volume":"32","author":"Ghanim","year":"2009","journal-title":"Diabetes Care"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0046","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MOL.0000000000000278","article-title":"Expanding role of gut microbiota in lipid metabolism","volume":"27","author":"Ghazalpour","year":"2016","journal-title":"Current Opinion in Lipidology"},{"key":"2023011711241171600_jam15740-bib-0047","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.5604\/01.3001.0010.5494","article-title":"The role of bile acids in glucose metabolism and their relation with diabetes","volume":"16","author":"Gonz\u00e1lez-Regueiro","year":"2017","journal-title":"Annals of Hepatology"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0048","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.4049\/jimmunol.1500130","article-title":"Subclinical-dose endotoxin sustains low-grade inflammation and exacerbates steatohepatitis in high-fat diet-fed mice","volume":"196","author":"Guo","year":"2016","journal-title":"Journal of Immunology"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0049","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/hep.26746","article-title":"IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice","volume":"59","author":"Harley","year":"2014","journal-title":"Hepatology"},{"issue":"12","key":"2023011711241171600_jam15740-bib-0050","doi-asserted-by":"crossref","first-page":"1700300","DOI":"10.1002\/mnfr.201700300","article-title":"Consumption of two healthy dietary patterns restored microbiota dysbiosis in obese patients with metabolic dysfunction","volume":"61","author":"Haro","year":"2017","journal-title":"Molecular Nutrition & Food Research"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0051","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/21623945.2016.1252011","article-title":"Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes","volume":"5","author":"Heimann","year":"2016","journal-title":"Adipocyte"},{"issue":"7384","key":"2023011711241171600_jam15740-bib-0052","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"2023011711241171600_jam15740-bib-0053","first-page":"237","article-title":"Probiotics: achieving a better regulatory fit","volume":"69","author":"Hofmann","year":"2014","journal-title":"Food and Drug Law Journal"},{"issue":"7","key":"2023011711241171600_jam15740-bib-0054","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134333","article-title":"Obesity alters the microbial community profile in Korean adolescents","volume":"10","author":"Hu","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s40168-018-0590-5","article-title":"The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids","volume":"6","author":"Huang","year":"2018","journal-title":"Microbiome"},{"key":"2023011711241171600_jam15740-bib-0056","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of IL-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0057","doi-asserted-by":"crossref","first-page":"386","DOI":"10.18632\/aging.101743","article-title":"Loss of GPR109A\/HCAR2 induces aging-associated hepatic steatosis","volume":"11","author":"Jadeja","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0058","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1467-789X.2009.00569.x","article-title":"The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes","volume":"10","author":"Jia","year":"2009","journal-title":"Obesity Reviews"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0059","doi-asserted-by":"crossref","first-page":"2021790","DOI":"10.1080\/19490976.2021.2021790","article-title":"Hybrid, ultra-deep metagenomic sequencing enables genomic and functional characterization of low-abundance species in the human gut microbiome","volume":"14","author":"Jin","year":"2022","journal-title":"Gut Microbes"},{"key":"2023011711241171600_jam15740-bib-0060","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.chom.2019.05.005","article-title":"Daily sampling reveals personalized diet-microbiome associations in humans","volume":"25","author":"Johnson","year":"2019","journal-title":"Cell Host & Microbe"},{"issue":"36","key":"2023011711241171600_jam15740-bib-0061","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0804437105","article-title":"Functional and comparative metagenomic analysis of bile salt hydrolase activity in the humans gut microbiome","volume":"105","author":"Jones","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0062","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4082\/kjfm.2013.34.2.80","article-title":"Effect of Lactobacillus gasseri BNR17 on overweight and obese adults: a randomized, double-blind clinical trial","volume":"34","author":"Jung","year":"2013","journal-title":"Korean Journal of Family Medicine"},{"key":"2023011711241171600_jam15740-bib-0063","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3945\/ajcn.117.156380","article-title":"Time of day and eating behaviors are associated with the composition and function of the human gastrointestinal microbiota","volume":"106","author":"Kaczmarek","year":"2017","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"6","key":"2023011711241171600_jam15740-bib-0064","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ejcn.2010.19","article-title":"Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial","volume":"64","author":"Kadooka","year":"2010","journal-title":"European Journal of Clinical Nutrition"},{"key":"2023011711241171600_jam15740-bib-0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12876-015-0330-2","article-title":"Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing","volume":"15","author":"Kasai","year":"2015","journal-title":"BMC Gastroenterology"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0066","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/nu7042839","article-title":"Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation","volume":"7","author":"Kasubuchi","year":"2015","journal-title":"Nutrients"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0067","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13073-021-00950-7","article-title":"Human reference gut microbiome catalog including newly assembled genomes from under-represented Asian metagenomes","volume":"13","author":"Kim","year":"2021","journal-title":"Genome Med"},{"key":"2023011711241171600_jam15740-bib-0068","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nature Communications"},{"issue":"6","key":"2023011711241171600_jam15740-bib-0069","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41564-018-0172-0","article-title":"Microbial metabolic gatekeeping in the jejunum","volume":"3","author":"Kleerebezem","year":"2018","journal-title":"Nature Microbiology"},{"key":"2023011711241171600_jam15740-bib-0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12937-016-0166-9","article-title":"Pathophysiological role of host microbiota in the development of obesity","volume":"15","author":"Kobyliak","year":"2016","journal-title":"Nutrition Journal"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0071","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nature Medicine"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0072","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/metabo11010055","article-title":"Linking gut microbiome and lipid metabolism: moving beyond associations","volume":"11","author":"Lamichhane","year":"2021","journal-title":"Metabolites"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0073","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.gastro.2019.08.024","article-title":"Red wine consumption associated with increased gut microbiota \u03b1-diversity in 3 independent cohorts","volume":"158","author":"Le Roy","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0074","doi-asserted-by":"crossref","first-page":"777","DOI":"10.14336\/AD.2019.0926","article-title":"\u03b2-Hydroxybutyrate suppresses lipid accumulation in aged liver through GPR109A-mediated signaling","volume":"11","author":"Lee","year":"2020","journal-title":"Aging and Disease"},{"issue":"31","key":"2023011711241171600_jam15740-bib-0075","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7122","key":"2023011711241171600_jam15740-bib-0076","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"issue":"9","key":"2023011711241171600_jam15740-bib-0077","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.3390\/nu13093211","article-title":"Effects and mechanisms of probiotics, prebiotics, synbiotics, and postbiotics on metabolic diseases targeting gut microbiota: a narrative review","volume":"13","author":"Li","year":"2021","journal-title":"Nutrients"},{"key":"2023011711241171600_jam15740-bib-0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2020.109132","article-title":"Study on intestinal survival and cholesterol metabolism of probiotics","volume":"124","author":"Liang","year":"2020","journal-title":"LWT"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0079","doi-asserted-by":"crossref","first-page":"565","DOI":"10.15171\/apb.2018.065","article-title":"Effects of prebiotic and synbiotic supplementation on glycaemia and lipid profile in type 2 diabetes: a meta-analysis of randomized controlled trials","volume":"8","author":"Mahboobi","year":"2018","journal-title":"Advanced Pharmaceutical Bulletin"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/bacteroides ratio of the human microbiota changes with age","volume":"9","author":"Mariat","year":"2009","journal-title":"BMC Microbiology"},{"issue":"13","key":"2023011711241171600_jam15740-bib-0081","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1097\/01.MIB.0000435444.14860.ea","article-title":"G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells","volume":"19","author":"Masui","year":"2013","journal-title":"Inflammatory Bowel Diseases"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0082","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1271\/bbb.70474","article-title":"Voluntary running exercise alters microbiota composition and increases n-butyrate concentration in the rat cecum","volume":"72","author":"Matsumoto","year":"2008","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0083","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125889","article-title":"Exercise is more effective at altering gut microbial composition and producing stable changes in lean mass in juvenile versus adult male F344 rats","volume":"10","author":"Mika","year":"2015","journal-title":"PLoS ONE"},{"key":"2023011711241171600_jam15740-bib-0084","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.arcmed.2017.11.003","article-title":"Gut microbiota in obesity and metabolic abnormalities: a matter of composition or functionality?","volume":"48","author":"Moran-Ramos","year":"2017","journal-title":"Archives of Medical Research"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"2023011711241171600_jam15740-bib-0086","doi-asserted-by":"crossref","DOI":"10.1038\/s41396-021-00998-8","article-title":"Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients","volume":"15","author":"Ni","year":"2021","journal-title":"The ISME Journal"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0087","doi-asserted-by":"crossref","first-page":"425","DOI":"10.5551\/jat.15065","article-title":"Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages","volume":"20","author":"Ohira","year":"2013","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"issue":"12","key":"2023011711241171600_jam15740-bib-0088","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/oby.21230","article-title":"Probiotic supplementation attenuates increases in body mass and fat mass during high-fat diet in healthy young adults","volume":"23","author":"Osterberg","year":"2015","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0089","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0022-4804(91)90078-Z","article-title":"Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat","volume":"51","author":"Pappo","year":"1991","journal-title":"The Journal of Surgical Research"},{"issue":"2","key":"2023011711241171600_jam15740-bib-0090","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1271\/bbb.70581","article-title":"Effects of Lactobacillus acidophilus 43121 and a mixture of Lactobacillus casei and Bifidobacterium longum on the serum cholesterol levels and fecal sterol excretion in hypercholesterolemia-induced pigs","volume":"72","author":"Park","year":"2008","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"2023011711241171600_jam15740-bib-0091","doi-asserted-by":"crossref","first-page":"20683","DOI":"10.1038\/srep20683","article-title":"Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats","volume":"6","author":"Paul","year":"2016","journal-title":"Scientific Reports"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0092","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/1471-2164-15-511","article-title":"Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats","volume":"15","author":"Petriz","year":"2014","journal-title":"BMC Genomics"},{"key":"2023011711241171600_jam15740-bib-0093","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tifs.2016.08.011","article-title":"Gut microbiota role in dietary protein metabolism and health-related outcomes: the two sides of the coin","volume":"57","author":"Portune","year":"2016","journal-title":"Trends in Food Science and Technology"},{"key":"2023011711241171600_jam15740-bib-0094","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/oby.22175","article-title":"Gut microbes and health: a focus on the mechanisms linking microbes, obesity, and related disorders","volume":"26","author":"Rastelli","year":"2018","journal-title":"Obesity (SilverSpring)"},{"issue":"11","key":"2023011711241171600_jam15740-bib-0095","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.3382\/ps.2012-02489","article-title":"Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens","volume":"91","author":"Rauber","year":"2012","journal-title":"Poultry Science"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0096","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1017\/S0954422416000226","article-title":"Mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotics","volume":"30","author":"Reis","year":"2017","journal-title":"Nutrition Research Reviews"},{"key":"2023011711241171600_jam15740-bib-0097","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"2023011711241171600_jam15740-bib-0098","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.3390\/ijms21165793","article-title":"Obesity and COVID-19: molecular mechanisms linking both pandemics","volume":"21","author":"Ritter","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"Suppl. 2","key":"2023011711241171600_jam15740-bib-0099","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"The British Journal of Nutrition"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0100","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0115426506021004351","article-title":"Short-chain fatty acids: ready for prime time?","volume":"21","author":"Roy","year":"2006","journal-title":"Nutrition in Clinical Practice"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0101","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","article-title":"Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases","volume":"51","author":"Sanna","year":"2019","journal-title":"Nature Genetics"},{"key":"2023011711241171600_jam15740-bib-0102","doi-asserted-by":"crossref","first-page":"16643","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Scientific Reports"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0103","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1194\/jlr.M051680","article-title":"Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis","volume":"56","author":"Shih","year":"2015","journal-title":"Journal of Lipid Research"},{"key":"2023011711241171600_jam15740-bib-0104","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/eurheartj\/ehs263","article-title":"Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction","volume":"34","author":"Simon","year":"2013","journal-title":"European Heart Journal"},{"key":"2023011711241171600_jam15740-bib-0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature18846","article-title":"Diet-microbiota interactions as moderators of human metabolism","volume":"535","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"issue":"11","key":"2023011711241171600_jam15740-bib-0107","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","article-title":"The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics","volume":"17","author":"Swanson","year":"2020","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0108","doi-asserted-by":"crossref","first-page":"e01018","DOI":"10.1128\/mBio.01018-16","article-title":"Looking for a signal in the noise: revisiting obesity and the microbiome","volume":"7","author":"Sze","year":"2016","journal-title":"mBio"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-014-0214-1","article-title":"Is serum Interleukin-17 associated with early atherosclerosis in obese patients?","volume":"12","author":"Tarantino","year":"2014","journal-title":"Journal of Translational Medicine"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0110","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2217\/fmb.15.13","article-title":"Systematic review on intervention with prebiotics\/probiotics in patients with obesity-related nonalcoholic fatty liver disease","volume":"10","author":"Tarantino","year":"2015","journal-title":"Future Microbiology"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0111","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/microorganisms10010052","article-title":"What is the role of gut microbiota in obesity prevalence? A few words about gut microbiota and its association with obesity and related diseases","volume":"10","author":"Tokarek","year":"2021","journal-title":"Microorganisms"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0112","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/physrev.2001.81.3.1031","article-title":"Short-chain fatty acids and human colonic function: roles of resistant starch and non-starch polysaccharides","volume":"81","author":"Topping","year":"2001","journal-title":"Physiological Reviews"},{"key":"2023011711241171600_jam15740-bib-0113","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/690752","article-title":"Cholesterol-lowering potentials of lactic acid bacteria based on bile-salt hydrolase activity and effect of potent strains on cholesterol metabolism in vitro and in vivo","volume":"2014","author":"Tsai","year":"2014","journal-title":"Scientific World Journal"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0114","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s13679-019-00352-2","article-title":"Understanding the role of the gut microbiome and microbial metabolites in obesity and obesity-associated metabolic disorders: current evidence and perspectives","volume":"8","author":"Vallianou","year":"2019","journal-title":"Current Obesity Reports"},{"issue":"3","key":"2023011711241171600_jam15740-bib-0115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13679-020-00379-w","article-title":"Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives","volume":"9","author":"Vallianou","year":"2020","journal-title":"Current Obesity Reports"},{"issue":"36","key":"2023011711241171600_jam15740-bib-0116","first-page":"E8489","article-title":"Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa","volume":"115","author":"Vonaesch","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0117","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0676.1987.tb00355.x","article-title":"Pattern of progression in liver injury following jejunoileal bypass for morbid obesity","volume":"7","author":"Vyberg","year":"1987","journal-title":"Liver"},{"issue":"4","key":"2023011711241171600_jam15740-bib-0118","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3168\/jds.2011-4768","article-title":"Selection of potential probiotic lactobacilli for cholesterol-lowering properties and their effect on cholesterol metabolism in rats fed a high-lipid diet","volume":"95","author":"Wang","year":"2012","journal-title":"Journal of Dairy Science"},{"key":"2023011711241171600_jam15740-bib-0119","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/ije\/dyz273","article-title":"Has the prevalence of overweight, obesity and central obesity levelled off in the United States? Trends, patterns, disparities, and future projections for the obesity epidemic","volume":"49","author":"Wang","year":"2020","journal-title":"International Journal of Epidemiology"},{"key":"2023011711241171600_jam15740-bib-0120","first-page":"14","article-title":"The potential role of probiotics in controlling overweight\/obesity and associated metabolic parameters in adults: a systematic review and meta-analysis","volume":"3862971","author":"Wang","year":"2019","journal-title":"Journal of Evidence-Based Complementary and Alternative Medicine"},{"issue":"19","key":"2023011711241171600_jam15740-bib-0121","doi-asserted-by":"crossref","first-page":"E4673","DOI":"10.3390\/ijms20194673","article-title":"Postbiotics and their potential applications in early life nutrition and beyond","volume":"20","author":"Wegh","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"2023011711241171600_jam15740-bib-0122","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"2023011711241171600_jam15740-bib-0123","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/s41396-019-0367-2","article-title":"The gut microbiota is largely independent of host genetics in regulating fat deposition in chickens","volume":"13","author":"Wen","year":"2019","journal-title":"The ISME Journal"},{"issue":"1","key":"2023011711241171600_jam15740-bib-0124","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/ps\/79.1.33","article-title":"Effects of Salmonella typhimurium lipopolysaccharide on broiler chickens","volume":"79","author":"Xie","year":"2000","journal-title":"Poultry Science"},{"issue":"7402","key":"2023011711241171600_jam15740-bib-0125","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"issue":"7800","key":"2023011711241171600_jam15740-bib-0126","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-020-2101-7","article-title":"Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate","volume":"579","author":"Zhao","year":"2020","journal-title":"Nature"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jam.15740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jam.15740","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/133\/5\/2915\/48732566\/jambio2915.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/133\/5\/2915\/48732566\/jambio2915.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T12:12:54Z","timestamp":1676203974000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/133\/5\/2915\/6988948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":125,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,11,1]]},"published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jam.15740","relation":{},"ISSN":["1365-2672","1364-5072"],"issn-type":[{"value":"1365-2672","type":"electronic"},{"value":"1364-5072","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,11,1]]}}}