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The biofilm formation and exopolysaccharide production by the different strains showed a strong influence of the growth medium on the expression of these properties. The evaluated strains evidenced different antibiotic susceptibility patterns by phenotypic tests, while the resistance genes were not always correlated with the phenotypic profiles. None of the evaluated strains showed lecithinase, gelatinase, or \u03b2-hemolytic activity. Based on the results obtained, Lactobacillus gasseri CRL 1320 and Lacticaseibacillus rhamnosus CRL 1332 were selected to advance in the design of the products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A wide variability in the properties expressed by beneficial vaginal lactic acid bacteria strains were shown, evidencing a strain-specific and independent behaviour of the species\/metabolic group where classified. The selection criteria applied provided a valuable tool for the selection of the best vaginal lactobacilli strains for their inclusion in formulas for vaginal application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance and Impact of the Study<\/jats:title>\n                    <jats:p>Since probiotics are an important tool for improving human health, the designed formula are an excellent alternative to reconstitute the vaginal microbiota and prevent\/treat urogenital tract infections in women. The results obtained contribute to deepen the characterization of homologous beneficial vaginal lactic acid bacteria and advance in the design of vaginal probiotic products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jam.15752","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T16:53:06Z","timestamp":1659199986000},"page":"3041-3058","source":"Crossref","is-referenced-by-count":10,"title":["Functional and safety characterization of beneficial vaginal lactic acid bacteria for the design of vaginal hygiene products"],"prefix":"10.1093","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-9367","authenticated-orcid":false,"given":"Jessica Alejandra","family":"Silva","sequence":"first","affiliation":[{"name":"CERELA-CONICET (Centro de Referencia para Lactobacilos- Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas de Argentina) San Miguel de Tucum\u00e1n Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-8801","authenticated-orcid":false,"given":"Antonella","family":"Marchesi","sequence":"additional","affiliation":[{"name":"CERELA-CONICET (Centro de Referencia para Lactobacilos- Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas de Argentina) San Miguel de Tucum\u00e1n Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-7751","authenticated-orcid":false,"given":"Mar\u00eda Cecilia","family":"Aristimu\u00f1o Ficosecco","sequence":"additional","affiliation":[{"name":"CERELA-CONICET (Centro de Referencia para Lactobacilos- Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas de Argentina) San Miguel de Tucum\u00e1n Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-1860","authenticated-orcid":false,"given":"Mar\u00eda Elena F\u00e1tima","family":"Nader-Mac\u00edas","sequence":"additional","affiliation":[{"name":"CERELA-CONICET (Centro de Referencia para Lactobacilos- Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas de Argentina) San Miguel de Tucum\u00e1n Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2023011711241156100_jam15752-bib-0001","doi-asserted-by":"crossref","first-page":"754","DOI":"10.24996\/ijs.2020.61.4.7","article-title":"Extraction and partial purification of Exo-polysaccharide from Lactobacillus rhamnosus isolated from vaginal specimens","author":"Alshammery","year":"2020","journal-title":"Iraqi Journal of 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