{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:38:10Z","timestamp":1770136690117,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008543","name":"Cyprus University of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bank of Cyprus Oncology Canter","award":["INT-480619-2012"],"award-info":[{"award-number":["INT-480619-2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To test the effectiveness of thymus honey as a complementary intervention for decreasing the salivary gland damage due to Radioiodine (<jats:sup>131<\/jats:sup>I) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Radioiodine is the treatment of choice in people diagnosed with thyroid cancer following total thyroidectomy. Although its value has been acknowledged in eradicating remnant thyroid tissue and treating residual disease in patients with visible, inoperable, iodine\u2010avid metastases, it has been associated with various salivary gland side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This is a randomized controlled trial with a 2\u00d73 mixed between\u2013within subjects design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 120 participants of postsurgical differentiated thyroid cancer, who will be referred to this centre for <jats:sup>131<\/jats:sup>I therapy to ablate the remnant thyroid tissue or to treat metastatic tumour, will be prospectively studied under varying regimens of lemon candy (standard treatment) and thymus honey mouthwashes (experimental intervention). Patients will be randomized in four equally numbered groups based on the assumptions and hypothesis of the study. The recruiting process will be informed by predefined inclusion and exclusion criteria. Mixed statistical modelling will be adopted taking into consideration between and within subjects' effects and repeated measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The recommended intervention protocol is expected to improve the comprehensive management of salivary gland\u2010related side effects induced by the radioiodine treatment in people diagnosed with thyroid cancer. Through the methodological approach chosen, the ideal intervention protocol in terms of the time to initiate the intervention and the frequency of the intervention to acquire optimal results in minimizing salivary glands damage will be tested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.12318","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T10:07:49Z","timestamp":1385028469000},"page":"1663-1671","source":"Crossref","is-referenced-by-count":8,"title":["A randomized controlled trial for the use of Thymus Honey in decreasing Salivary Gland Damage following Radioiodine Therapy for Thyroid cancer: research protocol"],"prefix":"10.1111","volume":"70","author":[{"given":"Andreas","family":"Charalambous","sequence":"first","affiliation":[{"name":"Cyprus University of Technology Limassol Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savvas","family":"Frangos","sequence":"additional","affiliation":[{"name":"Bank of Cyprus Oncology Centre Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michalis","family":"Talias","sequence":"additional","affiliation":[{"name":"Open University Cyprus Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21520"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed084p1643"},{"key":"e_1_2_8_4_1","first-page":"959","volume-title":"Diagnostic Nuclear Medicine","author":"Becker D.V.","year":"1995"},{"key":"e_1_2_8_5_1","first-page":"1237","article-title":"Radioprotection of salivary glands by amifostine in high\u2010dose radioiodine therapy","volume":"39","author":"Bohsulavizki K.H.","year":"1998","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_8_6_1","first-page":"1062","article-title":"Quantitative salivary gland scintigraphy in the diagnosis of parenchymal damage after radioiodine [Abstract]","volume":"23","author":"Bohuslavizki K.H.","year":"1996","journal-title":"European Journal of Nuclear Medicine"},{"key":"e_1_2_8_7_1","first-page":"5","article-title":"Is quantitative salivary gland scintigraphy a mandatory examination prior to and after radioiodine therapy","volume":"31","author":"Bohuslavizki K.H.","year":"1997","journal-title":"Radiation Oncology"},{"key":"e_1_2_8_8_1","first-page":"2214","article-title":"Complications, sequela and dosimetry of iodine\u2010131 therapy for thyroid carcinoma","volume":"33","author":"Bushnell D.L.","year":"1992","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2013.01.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01320"},{"key":"e_1_2_8_11_1","first-page":"658","volume-title":"The Thyroid and Its Diseases","author":"DeGroot I.J.","year":"1996"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0210-y"},{"issue":"14","key":"e_1_2_8_13_1","first-page":"7","article-title":"Using honey as a dressing for infected skin lesions","volume":"96","author":"Dunford C.","year":"2000","journal-title":"Nurs Times"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.105233"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.061382"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00428-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1139"},{"key":"e_1_2_8_19_1","volume-title":"SEER Cancer Statistics Review, 1975\u20102010","author":"Howlader N.","year":"2013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175858"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K06-166"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02984474"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0466"},{"key":"e_1_2_8_24_1","first-page":"20","article-title":"Quantitative salivary gland scintigraphy","volume":"27","author":"Klutmann S.","year":"1999","journal-title":"Nuclear Medicine Technology"},{"issue":"11","key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.6004\/jnccn.2010.0094","article-title":"Complications of radioactive iodine treatment of thyroid carcinoma","volume":"8","author":"Lee S.L.","year":"2010","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-7-199404010-00008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.6.1124"},{"key":"e_1_2_8_28_1","unstructured":"LoveridgeJ.(2001)The chemistry of Bees. 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