{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:32:15Z","timestamp":1787239935940,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Official Barcelona Nurses Association","award":["PR-1819-13"],"award-info":[{"award-number":["PR-1819-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy of nursing interventions on adherence to antituberculosis medication in a paediatric cohort (aged 0\u201018\u00a0years) and to identify the risk factors for non\u2010compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>After primary infection, children have a higher risk of developing tuberculosis and the severity of the disease is worse in children. Adherence to treatment is essential to control both latent infection and tuberculosis disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Phase 1: retrospective descriptive analysis (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      270) in children and young people receiving antituberculosis treatment. Phase 2: quasi\u2010experimental, longitudinal, prospective study (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      100). The results of the two phases will be compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Phase 1: in children followed up during the period 2011\u20132013 (non\u2010intervention group), the level of adherence and its associated epidemiological, sociocultural and clinical risk factors will be analysed. Phase 2: educational (written information in the child's mother tongue and follow\u2010up telephone calls) and monitoring (Eidus\u2010Hamilton test and follow\u2010up questionnaire) nursing interventions will be implemented. The results of the two phases will be compared. The definitive Nurse\u2010led Follow\u2010up Programme will then be designed. This project was funded in October 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The risk factors for poor adherence to antituberculosis therapy need to be identified to optimize treatment success in latent tuberculosis infection and disease in children and young people. Simultaneous application of several educational and monitoring methods in nurse\u2010led follow\u2010up shall improve adherence in children and adolescents in our setting. These results may also be applicable in other settings, where tuberculosis is more prevalent and directly observed treatment strategies are not available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.12656","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T19:24:03Z","timestamp":1427397843000},"page":"2189-2199","source":"Crossref","is-referenced-by-count":12,"title":["Influence of nursing interventions on adherence to treatment with antituberculosis drugs in children and young people: research protocol"],"prefix":"10.1111","volume":"71","author":[{"given":"Eva Maria","family":"Guix\u2010Comellas","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Nursing University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Librada","family":"Rozas\u2010Quesada","sequence":"additional","affiliation":[{"name":"Paediatric Tuberculosis Referral Unit Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enriqueta","family":"Force\u2010Sanmart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Nursing University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Maria","family":"Estrada\u2010Masllorens","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Nursing University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Galimany\u2010Masclans","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Noguera\u2010Julian","sequence":"additional","affiliation":[{"name":"Paediatric Tuberculosis Referral Unit Infectious Diseases Department of Paediatrics Hospital Sant Joan de D\u00e9u University of Barcelona 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