{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:36:37Z","timestamp":1758393397767},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 HL090513","R01 HL114404"],"award-info":[{"award-number":["U54 HL090513","R01 HL114404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To gain an in\u2010depth understanding of the perceptions of young adults with sickle cell disease and sickle cell trait about parenthood and participating in the <jats:styled-content style=\"fixed-case\">CHOICES<\/jats:styled-content> randomized controlled trial that used computer\u2010based, educational programmes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In the USA, there is insufficient education to assure that all young adults with sickle cell disease or sickle cell trait understand genetic inheritance risks and reproductive options to make informed reproductive decisions. To address this educational need, we developed a computer\u2010based, multimedia program (<jats:styled-content style=\"fixed-case\">CHOICES<\/jats:styled-content>) and reformatted usual care into a computer\u2010based (e\u2010Book) program. We then conducted a two\u2010year randomized controlled trial that included a qualitative component that would deepen understanding of young adults\u2019 perceptions of parenthood and use of computer\u2010based, educational programmes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A qualitative descriptive approach completed after a randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010eight men and women of childbearing age participated in semi\u2010structured interviews at the completion of the randomized controlled trial from 2012\u20132013. Thematic content analysis guided the qualitative description.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\/findings<\/jats:title><jats:p>Three main themes were identified: (1) increasing knowledge and new ways of thinking and behaving; (2) rethinking parenting plans; and (3) appraising the program design and delivery. Most participants reported increased knowledge and rethinking of their parenting plans and were supportive of computer\u2010based learning. Some participants expressed difficulty in determining individual transmission risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Participants perceived the computer programs as beneficial to their learning. Future development of an Internet\u2010based educational programme is warranted, with emphasis on providing tailored education or memory boosters about individual transmission risks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.12702","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T07:10:49Z","timestamp":1434352249000},"page":"1430-1440","source":"Crossref","is-referenced-by-count":14,"title":["Perception of young adults with sickle cell disease or sickle cell trait about participation in the <scp>CHOICES<\/scp> randomized controlled trial"],"prefix":"10.1111","volume":"72","author":[{"given":"Patricia E.","family":"Hershberger","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago College of Nursing Illinois USA"},{"name":"University of Illinois at Chicago College of Medicine Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agatha M.","family":"Gallo","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Nursing Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Molokie","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Illinois USA"},{"name":"University of Illinois at Chicago College of Pharmacy Illinois USA"},{"name":"University of Illinois Hospital and Health Sciences System Comprehensive Sickle Cell Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Northwestern University\u2010Feinberg School of Medicine Chicago Illinois USA"},{"name":"Division of Hematology\/Oncology\/Stem Cell Transplantation Ann and Robert H. 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