{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:23:07Z","timestamp":1760908987852},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to perform a systematic review of clinical trials covering interventions used as prophylaxis for oral mucositis induced by ambulatory antineoplastic chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral mucositis in patients undergoing chemotherapy is a side effect that can impact the quality of treatment and can interfere with eating and therapeutic adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Quantitative systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources<\/jats:title><jats:p>Relevant databases were searched, from January 2002\u2013July 2013, by using the combination of the keywords mucositis, stomatitis, neoplasms, antineoplastic agents, drug therapy, prevention and control and chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review methods<\/jats:title><jats:p>Two researchers independently read the titles and abstracts from every cross\u2010reference. The quality of the included studies was analysed by the Jadad Scale and the Cochrane Collaboration Risk of Bias Tool. Data were extracted from the selected studies with a data collection form developed specifically for this purpose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 23 controlled clinical trials that were identified in this study, five articles evaluated the use of oral cryotherapy to prevent oral mucositis and three studies analysed the prophylactic use of glutamine. Interventions of protocols for oral care, palifermin, allopurinol and chlorhexidine were evaluated by two articles each. Interventions of zinc sulphate, amifostine, chewing gum, sucralfate, recombination human intestinal trefoil factor, kefir and vitamin E were evaluated by one article each.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is strong evidence that cryotherapy can prevent oral mucositis arising from ambulatory treatment with 5\u2010flurouracil chemotherapy. Other interventions, although showing positive results in preventing oral mucositis, require further study to confirm their conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.12867","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T07:56:12Z","timestamp":1449042972000},"page":"735-746","source":"Crossref","is-referenced-by-count":29,"title":["Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review"],"prefix":"10.1111","volume":"72","author":[{"given":"Nat\u00e1lia de Melo","family":"Manzi","sequence":"first","affiliation":[{"name":"University of Bras\u00edlia (UnB) Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Cristina de Campos Pereira","family":"Silveira","sequence":"additional","affiliation":[{"name":"School of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto (SP) Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Elaine Diniz dos","family":"Reis","sequence":"additional","affiliation":[{"name":"Nursing Department School of Healthy Sciences University of Bras\u00edlia (UnB) Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"413","article-title":"Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy\u2010induced mucositis: a double\u2010blind randomized clinical trial","volume":"15","author":"Arbabi\u2010Kalati F.","year":"2002","journal-title":"Archives of Iranian Medicine"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1188\/05.CJON.584-592"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.10.023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.07.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0867-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5394.2000.86010.pp.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11671"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318030a3e4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1002\/9780470712184","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series (2008)","author":"Higgins J.P.T.","year":"2008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2005.01128.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2011.07.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28592"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.3.449"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2005.01156.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00520-002-0378-8","article-title":"Sucralfate mouthwash for prevention and treatment of 5\u2010fluorouracil\u2010induced mucositis: a randomized, placebo\u2010controlled trial","volume":"11","author":"Nottage M.","year":"2003","journal-title":"Supportive Care in Cancer"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2008.01042.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2006.05.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22384"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.2381"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1562-0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1391"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2006.00684.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1152"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872011000300015"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-00132012000200009"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01258.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2103::AID-CNCR2>3.0.CO;2-0"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23328"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000803600628"},{"key":"e_1_2_10_33_1","first-page":"3263","article-title":"Outcome of local application of amifostine (WR\u20101065) on epirubicin\u2010induced oral mucositis. 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