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Few interventions exist that effectively reduce fatigue in this population. Physical activity has shown promise to reduce fatigue in other populations, but its impact on fatigue in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> has not yet been explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This study was conducted using a prospective, descriptive cohort design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 90 adults living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> completed cross\u2010sectional measures. Home\u2010based physical activity was measured using a 7\u2010day self\u2010report diary. Fatigue was measured using the self\u2010reported <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010Related Fatigue Scale. Sleep was assessed using wrist actigraphy and quality of life was assessed using the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010Associated Quality of Life Scale. Data were collected from December 2012\u2013April 2013 and analysed using correlations and multiple linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of minutes of home\u2010based physical activity was significantly associated with reduced fatigue among people living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>. In addition, increased fatigue was associated with decreased quality of life. No associations were found among fatigue, sleep or gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that physical activity in the home setting is an effective strategy to reduce fatigue among people living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>. Future work developing and testing interventions to improve home\u2010based physical activity in this population is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.13084","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T09:04:45Z","timestamp":1470215085000},"page":"3104-3112","source":"Crossref","is-referenced-by-count":52,"title":["Physical activity is associated with reduced fatigue in adults living with <scp>HIV<\/scp>\/<scp>AIDS<\/scp>"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-5780","authenticated-orcid":false,"given":"Allison R.","family":"Webel","sequence":"first","affiliation":[{"name":"Frances Payne Bolton School of Nursing Case Western Reserve University Cleveland Ohio 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