{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:31:10Z","timestamp":1791815470309,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["RPPG\u20101210\u201012009"],"award-info":[{"award-number":["RPPG\u20101210\u201012009"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To systematically identify, evaluate and synthesize qualitative research that examined the symptoms and health\u2010related quality of life themes that are important from the perspective of patients with venous leg ulceration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Venous leg ulceration is a common chronic condition; the symptoms and associated treatments have a negative effect on health\u2010related quality of life. Qualitative research methods can provide insight into the personal experiences of patients with venous leg ulceration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Qualitative evidence synthesis (using framework synthesis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Multiple electronic databases including <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Psyc<jats:styled-content style=\"fixed-case\">INFO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content> were comprehensively searched from inception to November 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Systematic identification, quality assessment and synthesis of existing qualitative research were performed; framework synthesis was conducted on included studies. An inductive approach was used and emergent themes were identified. The final stage in the synthesis involved the development of new interpretations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen studies met the inclusion criteria; the overall quality of the included studies was good. Four overarching themes were identified; physical impact, psychological impact, social impact and treatment and, in these, further subthemes were identified. Ulcer and treatment\u2010related pain, as well as odour and exudate appeared to have significant and direct negative effects on quality of life, with additional and cumulative effects on sleep, mobility and mood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The themes identified in this review should be considered by professionals providing services, care and treatment for venous leg ulcer patients and in the selection, or development, of patient\u2010reported outcome measures for use with this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.13465","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:45:53Z","timestamp":1506613553000},"page":"550-563","source":"Crossref","is-referenced-by-count":124,"title":["A systematic review of qualitative research into people's experiences of living with venous leg ulcers"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-1527","authenticated-orcid":false,"given":"Patrick","family":"Phillips","sequence":"first","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"},{"name":"Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lumley","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"},{"name":"Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Duncan","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"},{"name":"Department of Nursing and Midwifery Sheffield Hallam University Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Aber","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Buckley","family":"Woods","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychology School of Social Sciences Leeds Beckett University Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Michaels","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-59"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2007.04348.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2005.14.17.19751"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2005.14.18.19888"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12199"},{"issue":"5","key":"e_1_2_8_7_1","first-page":"46","article-title":"Living with a chronic leg ulcer","volume":"24","author":"Byrne O.","year":"2010","journal-title":"Journal of Community Nursing"},{"issue":"9","key":"e_1_2_8_8_1","first-page":"571","article-title":"The impact of leg ulcers on patients\u2019 quality of life","volume":"10","author":"Charles H.","year":"1995","journal-title":"Professional Nurse (London, England)"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-0303(97)90004-2"},{"key":"e_1_2_8_10_1","volume-title":"CASP checklists","author":"Critical Appraisal Skills Programme (CASP)","year":"2014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2001.10.9.26318"},{"key":"#cr-split#-e_1_2_8_12_1.1","unstructured":"Duncan R. 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