{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:23:09Z","timestamp":1790709789744,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To identify the associations and effects of nutritional characteristics and interventions on ulcer outcomes in adult patients with venous leg ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Venous leg ulcers are the most prevalent type of lower limb ulcer; however, little evidence exists regarding the relationship between nutritional status and ulcer healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A systematic search of English language articles was conducted using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources<\/jats:title><jats:p>A search of databases Ovid<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, Cochrane,<jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>and Scopus was performed for studies published between January 2004 \u2010 May 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review methods<\/jats:title><jats:p>Quality of the included studies was assessed using the Cochrane Collaboration's Risk of Bias Assessment tool and the relevant Joanna Briggs Institute quality appraisal checklists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty studies met the inclusion criteria. All participants had Clinical Aetiology Anatomy Pathophysiology classification C5 (healed) or C6 (active) ulcers. Studies were conducted in a range of clinical settings with relatively small sample sizes. The majority of patients were overweight or obese. Increased body mass index was associated with delayed wound healing. Vitamin D, folic acid and flavonoids were associated with some beneficial effects on ulcer healing. Dietary intakes of omega\u20103 fatty acids, vitamin C and zinc were low for some patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current evidence suggests that venous leg ulcer patients are more likely to be overweight or obese. However, evidence for weight management improving wound healing is lacking. Micronutrients, including vitamin D and folic acid, may improve wound healing in at\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.13474","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T16:16:57Z","timestamp":1507306617000},"page":"774-787","source":"Crossref","is-referenced-by-count":50,"title":["Effects and associations of nutrition in patients with venous leg ulcers: A systematic review"],"prefix":"10.1111","volume":"74","author":[{"given":"Georgina A","family":"Barber","sequence":"first","affiliation":[{"name":"Faculty Medicine, Nursing and Health Sciences School of Nursing and Midwifery Monash University Melbourne Vic. Australia"},{"name":"School of Clinical Sciences Department Nutrition, Dietetics and Food Monash University Melbourne Vic. 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