{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:00:29Z","timestamp":1790870429961,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Official Barcelona Nurses Association","award":["PR-1819-13"],"award-info":[{"award-number":["PR-1819-13"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the association of a new nursing intervention on the adherence to antituberculosis treatment in a paediatric cohort (&lt;18\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tuberculosis remains a public health problem worldwide. The risk of developing tuberculosis after primary infection and its severity are higher in children. Proper adherence to antituberculosis treatment is critical for disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Nonrandomized controlled trial; Phase 1, retrospective (2011\u20132013), compared with Phase 2, prospective with intervention (2015\u20132016), in a referral centre for paediatric tuberculosis in Spain (\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      03230409).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 359 patients who received antituberculosis drugs after close contact with a smear\u2010positive patient (primary chemoprophylaxis) or were treated for latent tuberculosis infection or tuberculosis disease were included, 261 in Phase 1 and 98 in Phase 2.<\/jats:p>\n                    <jats:p>In Phase 2, a new nurse\u2010led intervention was implemented in all patients and included two educational steps (written information in the child's native language and follow\u2010up telephone calls) and two monitoring steps (Eidus\u2013Hamilton test and follow\u2010up questionnaire) that were exclusively carried out by nurses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adherence to antituberculosis treatment increased from 74.7% in Phase 1% to 87.8% in Phase 2 (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.014; Chi\u2010square test), after the implementation of the nurse\u2010led intervention. In Phase 2, nonadherence was only associated with being born abroad (28.6% vs. 7.8%;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.019; Chi\u2010square test) and with foreign origin families (27.3% vs. 0%;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0001; Chi\u2010square test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The nurse\u2010led intervention was associated to an increase in adherence to antituberculosis treatment. Immigrant\u2010related variables remained major risk factors for sub\u2010optimal adherence in a low\u2010endemic setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.13692","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:19:59Z","timestamp":1525393199000},"page":"1819-1830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of nursing interventions on adherence to treatment with antituberculosis drugs in children and young people: A nonrandomized controlled trial"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-7265","authenticated-orcid":false,"given":"Eva Maria","family":"Guix\u2010Comellas","sequence":"first","affiliation":[{"name":"School of Nursing Faculty of Medicine and Health Sciences Department of Medical and Surgical Nursing University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Librada","family":"Rozas\u2010Quesada","sequence":"additional","affiliation":[{"name":"Childhood Tuberculosis Specialist Unit Nursing Department Sant Joan de D\u00e9u Hospital Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eneritz","family":"Velasco\u2010Arnaiz","sequence":"additional","affiliation":[{"name":"Malalties infeccioses i resposta inflamat\u00f2ria sist\u00e8mica en pediatria Unitat d\u2032Infeccions Servei de Pediatria. 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