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Cumulative stress exposure over the first 14\u00a0days of life will be measured using the Neonatal Infant Stressor Scale. Blood will be collected weekly for the quantification of cytokines. Neurodevelopment will be assessed using the Neurobehavioral Assessment of the Preterm Infant and hair for quantification of hair cortisol will be collected at 35\u00a0weeks post menstrual age. Multiple linear regression and conditional process analysis will be used to analyse the relationships among stress exposure, inflammation and neurodevelopment. Linear mixed models will be used to determine inflammatory trajectories over time. IRB approval for the study was received May 2017, and funding from the National Institute of Nursing Research was awarded July 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study will determine the extent to which inflammation mediates the relationship between stress exposure and neurodevelopment. Interventions to attenuate inflammation in preterm infants may improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>Determining the potentially modifiable mediators of stress exposure and neurodevelopment in preterm infants is critical to improving long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.14079","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T05:27:23Z","timestamp":1558502843000},"page":"2236-2245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inflammatory mediators of stress exposure and neurodevelopment in very preterm infants: Protocol for the stress neuro\u2010immune study"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-5719","authenticated-orcid":false,"given":"Marliese Dion","family":"Nist","sequence":"first","affiliation":[{"name":"College of Nursing The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita H.","family":"Pickler","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah K.","family":"Steward","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-7029","authenticated-orcid":false,"given":"Tondi M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail B.","family":"Shoben","sequence":"additional","affiliation":[{"name":"College of Public Health, Division of Biostatistics The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2816"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520110033025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3351"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.06.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.042"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01695.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.03.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211403"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202246"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.09.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.09.003"},{"key":"e_1_2_9_15_1","article-title":"Executive functioning deficits in young adult survivors of bronchopulmonary dysplasia","volume":"1","author":"Gough A.","year":"2015","journal-title":"Disability and Rehabilitation"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584898"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073926"},{"issue":"8","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/AJP.0b013e3181e5bb00","article-title":"Cortisol, behavior and heart rate reactivity to immunization pain at 4 months corrected age in infants born very preterm","volume":"26","author":"Grunau R. 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