{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:40:22Z","timestamp":1780324822701,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005318","name":"Landseed Hospital","doi-asserted-by":"publisher","award":["LS\u20102014\u201009"],"award-info":[{"award-number":["LS\u20102014\u201009"]}],"id":[{"id":"10.13039\/501100005318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of a modified four\u2010session Comprehensive Behavioral Intervention for Tics programme for decreasing tics in children and adolescents with Tourette's syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comprehensive Behavioral Intervention for Tics programme has been shown to decrease tic severity. However, the lack of behaviour therapists in countries, such as in Taiwan, may preclude application of the standard eight\u2010session, 10\u2010week programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants aged 6\u201318\u00a0years diagnosed with Tourette's syndrome or chronic tic disorder were recruited from February 2015 through September 2016. Participants in the control and intervention groups (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a023 each) received the routine care (daily pyridoxine [50\u00a0mg] and psychoeducation). The intervention group received additional four behavioural intervention sessions over a 3\u2010month period that included psychoeducation, habit reversal training, relaxation training, and education on tic relapse prevention. The outcome measures, Yale Global Tic Severity Scale scores, were assessed at before and after the completion of programme for both groups and again at 3\u00a0months follow\u2010up for the intervention group. The effect of the intervention on severity scores was assessed using a generalized estimated equation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Comparison of scores before and after intervention showed that the intervention significantly decreased the severity of total motor tics (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a0\u22123.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) and total tics (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a0\u22125.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) as compared with control treatment. YGTSS scores for the intervention group were lower at 3\u2010month follow\u2010up as compared with before treatment or immediately after treatment completion (total tics,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The modified four\u2010session Comprehensive Behavioral Intervention for Tics programme was more effective than routine care for decreasing tic severity in our cohort of 6\u2010 to 18\u2010year olds. This improvement was maintained 3\u00a0months after intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>Healthcare providers, including nurses, in countries currently not adopting Comprehensive Behavioral Intervention for Tics programme should be made aware of the positive effects of this modified intervention for Tourette's syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.14279","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T23:41:05Z","timestamp":1574984465000},"page":"903-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effectiveness of a modified comprehensive behavioral intervention for tics for children and adolescents with tourette's syndrome: A randomized controlled trial"],"prefix":"10.1111","volume":"76","author":[{"given":"Chia\u2010Wen","family":"Chen","sequence":"first","affiliation":[{"name":"School of Nursing College of nursing Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei\u2010Shyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Chang Gung Children's Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-0712","authenticated-orcid":false,"given":"Hsiu\u2010Ju","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Nursing College of nursing Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Wei","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Landseed International Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2015.06.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(88)90089-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i10.569"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3182829f2b"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/02796015.2001.12086097","article-title":"A school\u2010based intervention designed to reduce the frequency of Tics in children with Tourette's syndrome","volume":"30","author":"Clarke M. 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