{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:11:35Z","timestamp":1785247895397,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To evaluate the effectiveness and safety of\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      skin patches for patients with acute gouty arthritis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In China, patients with acute gouty arthritis benefit from skin patcheses with herbal medicines. But the clinical effects of skin patches with\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      are rarely reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A Randomized, Double\u2010Blind, Active\u2010Controlled Trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The trial was performed from January 2015\u2013December 2018 at the First Affiliated Hospital of Sun Yat\u2010sen University in China. It was conducted with one intervention group (skin patches of\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      ,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a030) and one active control group (skin patches of Diclofenac Diethylamine Emulgel,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a031). Participants and study investigators were both blinded to the treatment assignments. The primary outcomes were the improvement of joints' symptoms. The secondary outcomes were changes in white blood cells, erythrocyte sedimentation rate and C\u2010reactive protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Skin patches of\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      showed quick effect on decreasing joint pain at 3rd day of treatment. Wherever only at 7th day, Diclofenac Diethylamine Emulgel markedly lowered joint pain.\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      also showed superior effect than Diclofenac Diethylamine Emulgel on improving joint swelling and range of motion and decreasing the levels of C\u2010reactive protein and erythrocyte sedimentation rate. No adverse reactions were observed in skin patches of\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Skin patches of\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      appeared to be safe and efficacious for relieving joint symptoms in patients with acute gouty arthritis. The mechanism might be associated with the decreased levels of C\u2010reactive protein and erythrocyte sedimentation rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      Skin\u2010patcheses with\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      are more effective than Diclofenac Diethylamine Emulgel on improving joint pain, swelling and range of motion.\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      treatment showed superior effects compared with Diclofenac Diethylamine Emulgel on decreasing levels of C\u2010reactive protein and erythrocyte sedimentation rate. Patients with acute gouty arthritis may benefit from skin patches of\n                      <jats:italic>Xin Huang Pian<\/jats:italic>\n                      for effective relief from joint pain and swelling.\n                    <\/jats:p>\n                    <jats:p>Chinese Clinical Trial Registration: ChiCTR\u2010TRC\u20101300 4122.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.14338","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T09:34:15Z","timestamp":1582882455000},"page":"1416-1424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Retracted:<\/i>\n                    Skin\u2010patch of\n                    <i>Xin Huang Pian<\/i>\n                    on relieving joint symptoms in patients with acute gouty arthritis: A Randomized, Double\u2010Blind, Active\u2010Controlled Trial"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1843-0928","authenticated-orcid":false,"given":"Bi\u2010Yu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine the First Affiliated Hospital Sun Yat\u2010sen University Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine the First Affiliated Hospital Sun Yat\u2010sen University Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Guo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine the First Affiliated Hospital Sun Yat\u2010sen University Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine the First Affiliated Hospital Sun Yat\u2010sen University Guangzhou P.R. 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