{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:20:18Z","timestamp":1790032818099,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["5T32NR0 14213\u201003"],"award-info":[{"award-number":["5T32NR0 14213\u201003"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Nursing"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the association between symptoms severity and treatment burden in people living with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Correlational, secondary analysis of data from participants diagnosed with HIV enrolled in a descriptive, cross\u2010sectional study examining physical activity patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from 103 men and women using self\u2010report data collected between March 2016 \u2010 February 2017. Our primary statistical analyses consisted of explanatory multivariate modelling with individual PROMIS\u201029 scores representing symptom severity and treatment burden measured using the Treatment Burden Questionnaire\u201013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Greater symptom severity was associated with higher levels of cumulative treatment burden as well as higher levels of task\u2010specific medication and physical activity burden. Multivariate regression analyses revealed that fatigue was a risk factor of cumulative treatment burden as well as task\u2010specific medication and physical activity treatment burden. Effect sizes of multivariate models ranged from small (0.11) to medium (0.16). Additionally, post hoc analyses showed strong correlations between fatigue and other measured symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings support extant treatment burden literature, including the importance of addressing symptom severity in conjunction with treatment burden screening in the clinical setting. Results also suggest clinical interventions focused on the reduction of fatigue could reduce treatment burden in people living with HIV. Strong correlations between fatigue and other symptoms indicate the potential for reducing fatigue by addressing other highly clustered symptoms, such as depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>People living with HIV exhibiting higher levels of fatigue are at high risk for treatment burden and poorer self\u2010management adherence. Clinicians should consider incorporating symptom and treatment burden assessments when developing, tailoring and modifying interventions to improve self\u2010management of HIV and other co\u2010morbid conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jan.14461","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T04:56:18Z","timestamp":1594270578000},"page":"2348-2358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations between symptom severity and treatment burden in people living with HIV"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-9561","authenticated-orcid":false,"given":"Nathanial","family":"Schreiner","sequence":"first","affiliation":[{"name":"Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Perazzo","sequence":"additional","affiliation":[{"name":"University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Digennaro","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Burant","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Daly","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-5780","authenticated-orcid":false,"given":"Allison","family":"Webel","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2012.712669"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-014-0917-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182a977da"},{"issue":"182","key":"e_1_2_9_5_1","first-page":"1","article-title":"Effectiveness of aerobic exercise for adults living with HIV: Systematic review and meta\u2010analysis using the Cochrane Collaboration protocol","volume":"16","author":"Brien K. 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